| NO-cGMP-Glu-[Ca~(2 )]i途径在隔-海马通路损伤的大鼠学习功能障碍中的作用 |
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| 引用本文： | 王景华,杨贵贞.NO-cGMP-Glu-[Ca~(2 )]i途径在隔-海马通路损伤的大鼠学习功能障碍中的作用[J].中国神经免疫学和神经病学杂志,1997(4). |
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| 作者姓名： | 王景华 杨贵贞 |
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| 作者单位： | 白求恩医科大学免疫教研室!长春，130021，白求恩医科大学免疫教研室!长春，130021 |
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| 摘 要： | 为探讨海马中一氧化氮影响大鼠学习能力的机制，观察海马中一氧化氮（NO）降低后海马cGMP、谷氨酸（Glu）、胞内游离钙离子（Ca2 ]i）含量的变化。结果表明海马中NO降低的同时cGMP、Glu和Ca2 ]i也降低。提示海马中NO可能是通过NO－cGMP－Gin-Ca2 ]i途径影响大鼠的学习能力。
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| 关 键 词： | 一氧化氮 cGMP 谷氨酸 胞内游离钙离子 学习能力 |
The Effects of Intrahippocampal Nitric Oxide on Learning Ability via NO-cGMP-Glu-[Ca~(2 )]i Pathway in Rats |
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| Wang Jinghua, Yang Guizhen.The Effects of Intrahippocampal Nitric Oxide on Learning Ability via NO-cGMP-Glu-[Ca~(2 )]i Pathway in Rats[J].Chinese Journal of Neuroimmunology and Neurology,1997(4). |
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| Authors: | Wang Jinghua Yang Guizhen |
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| Abstract: | Objective To study the concentration of intrahippocampal nitric oxide effecting learning ability of rats. Mathods The changes of intrahippocampal cGMP, glutamate and Ca2 ]i contents were determined in hippocampal tissue of rats with septo-hippocampal damages. Results The level of intrahippocampal cGMP, glutamate and Ca2 ]i were significantly decreased as the level of intrahippeampal nitric oxide was declining. Conclusion intrahippocampal nitric oxdie effects learning ability via NO-cGMP- Gln- Ca2 ]i pathway in rat. |
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| Keywords: | nitric oxide cGMP glutamate [Ca~(2 )] i learning ability |
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