| HPLC法测定甲磺酸伊马替尼片的含量 |
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| 引用本文： | 赵海桥,刘存领,付建,苏贵勇. HPLC法测定甲磺酸伊马替尼片的含量[J]. 齐鲁药事, 2012, 31(11): 646-647 |
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| 作者姓名： | 赵海桥 刘存领 付建 苏贵勇 |
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| 作者单位： | 1. 山东方明药业集团股份有限公司,山东,东明274500;山东大学药学院,山东,济南250012
2. 山东方明药业集团股份有限公司,山东,东明274500;中国药科大学药学院,江苏,南京210009 |
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| 摘 要： | 目的建立高效液相色谱法测定甲磺酸伊马替尼片含量的方法。方法色谱柱为Kromasil C18(4.6 mm×250mm,5μm),以含0.04%辛烷磺酸钠的20 mmol.L-1磷酸二氢钠溶液(磷酸调至pH 2.5)-甲醇(40:60)为流动相,流速为1.0 mL.min-1,检测波长为268 nm,柱温为30℃。结果甲磺酸伊马替尼在25.055～501.1μg.mL-1浓度范围内线性关系良好,r=0.999 9;RSD均小于2%;加样回收率在99.54%～101.23%之间。结论该方法准确、简便、快速,可用于甲磺酸伊马替尼片的含量测定。
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| 关 键 词： | 甲磺酸伊马替尼片 含量测定 高效液相色谱法 |
Determination of Imatinib Mesylate Tablets by HPLC |
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| ZHAO Hai-qiao , LIU Cun-ling , FU Jian , SU Gui-yong. Determination of Imatinib Mesylate Tablets by HPLC[J]. qilu pharmaceutical affairs, 2012, 31(11): 646-647 |
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| Authors: | ZHAO Hai-qiao LIU Cun-ling FU Jian SU Gui-yong |
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| Affiliation: | 1,2(1.Shandong Fangming Pharmaceutical Group Co.,Ltd.,Dongming 274500,China;2.School of Pharmacy, Shandong University,Jinan 250012,China;3.School of Pharmacy,China Pharmaceutical University,Nanjing 210009,China) |
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| Abstract: | Objective To establish an HPLC method for the determination of Imatinib Mesylate Tablets. Methods Kromsil C is column（ 4.6 mm × 250 ram,5 μm）was adopted with 20 mmol· L^-1 sodium dihydrogen phosphate containing 0.04% octane sulfonic acid sodium salt（ adjusted pH to 2.5 with H3PO4） -methanol（40： 60）as the mobile phase at the flow rate of 1.0 mL · min^-1. The detection wavelength was 268 nm. The column temperature was 30 ℃. Results The imatinib mesylate showed a good linear relationship within the range of 25. 055 - 501.1μg · mL^- 1 ,r = 0. 999 9. All the RSD were less than 2%. The average recoveries were 99.54% - 101.23%. Conclusion This method was accurate,simple and rapid,and it can be used for the determination of Imatinib Mesylate Tablets. |
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| Keywords: | hnatinib Mesylate Tablets Determination HPLC |
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