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Synthesis, analgesic and anti-inflammatory activity of 4-(2-phenoxyphenyl)semicarbazones |
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| Authors: | Rineh Ardeshir Mahmoodi Nosratollah Abdollahi Mohammad Foroumadi Alireza Sorkhi Maedeh Shafiee Abbas |
| Affiliation: | Department of Chemistry, University of Guilan, Rasht, Iran. |
| Abstract: | A series of 4-(2-phenoxyphenyl)semicarbazones was synthesized and evaluated for their analgesic and anti-inflammatory activities. Several compounds (e. g. 10h, 10i, and 11i) were found to be more potent than the reference drug mefenamic acid in the formalin test. Based on the results of an anti-inflammatory study, 1-(1-(2,5-dimethoxyphenyl)ethylidene)-4-(2-phenoxyphenyl)semicarbazide 11i was the most active compound. |
| Keywords: | Analgesic activity Anti‐inflammatory activity Semicarbazones |
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