正交试验优选八宝通脉颗粒制备工艺

目的：优选八宝通脉颗粒制备工艺。方法：以提取次数、加水量、提取时间为考察因素，以芍药苷得率和得膏率的综合评分为评价指标，采用正交试验优选水提取工艺；以颗粒收率、溶解率、吸湿率的综合评分为评价指标，采用单因素试验对填充剂种类进行考察，并测定颗粒的流动性和临界相对湿度。结果：最佳提取工艺为加8倍量的水提取3次，每次1h；最优填充剂为麦芽糊精，颗粒的流动性较好，其临界相对湿度为59．07％。结论：优选的工艺合理、可行，可用于八宝通脉颗粒的制备。

Optimization of Preparation Process of Babao Tongmai Granules by Orthogonal Test

OBJECTIVE： To optimize preparation process of Babao tongmai granules. METHODS： The water extraction technology of Babao tongmai granules was optimized by orthogonal test with extracting times, amount of water adding and extracting time as factors using extraction rate of paeoniflorin and yield of extracts as index. The kind of filler were investigated by single fac- tor test with yield, solubility and moisture absorption as index. RESULTS： The optimum technology was as follows： 8 times of water, extracting 3 times, lasting for 1 h each time. The optimum was maltodextrin, and the RCH of the granule was 59.07%. CONCLUSIONS： The optimal process is reasonable and feasible, and it could be suitable for the preparation of Babao tongmai granules.