双歧三联活菌对戒烟后腹泻的改善效应及安全性观察

目的：观察双歧三联活菌对戒烟后腹泻的改善效应及安全性。方法：130例戒烟后腹泻患者按用药情况分为黄连素对照组（n=30，黄连素片0．9g、tid）、双歧三联活菌组（n=50，双歧三联活菌胶囊420mg、tid）、黄连素双歧三联活菌联合组（n=50，同时服用黄连素片0．9g、tid及双歧三联活菌胶囊420mg、tid）。动态观察脱水、腹泻症状改善情况，并评估双歧三联活菌的安全性。结果：所有脱水病例治疗后脱水症状均消失。在第1天，双歧三联活菌组及黄连素双歧三联活菌联合组有效率即显著高于黄连素对照组（P〈0．05）；第2、3天，双歧三联活菌组及黄连素双歧三联活菌联合组显效率及有效率均显著高于黄连素对照组（P〈0．05或P〈0．01），无效率显著低于黄连素对照组（P〈0．05或P〈0．01）。而双歧三联活菌组及黄连素双歧三联活菌联合组比较，各项指标差异均无统计学意义。治疗过程中，未出现与服用双歧三联活菌有关的毒副作用和其他不良反应。结论：双歧三联活菌对戒烟后腹泻有明显疗效，值得推广应用；双歧三联活菌、黄连素无明显协同治疗效果。

Improvement Effect and Safety of Bifid Tiple Viable for Diarrhea after Smoke Abatement

OBJECTIVE： To observe the improvement effect and safety of bifid tiple viable for diarrhea after smoke abatement. METHODS： 130 cases of diarrhea after smoke abatement were divided into three groups according to different drug usage： berberine control group （n=30, Berberine tablet 0.9 g, tid）, bifid tiple viable group （n=50, Bifid tiple viable capsule 420 mg, tid） and drug combination group （n=50, Berberine tablet 0.9 g, tid; Bifid tiple viable capsule 420 mg, tid）. The symptoms of olighydria and diarrhea were observed dynamically. The safety of bifid tiple viable was evaluated. RESULTS： No olighydria was observed after treatment. On the first day, the effective rates of bifid tiple viable group and drug combination group were significantly higher than those of berberine control group （P〈0.05） ; on the second and third day, the effective rate and excellent rate of bifid tiple viable group and drug combination group were significantly higher than those of berberine control group （P〈0.05 or P〈0.01） ; ineffective rates of both groups were significantly lower than those of berberine control group （P〈0.05 or P〈0.01）. There was no statistical significance between bifid tiple viable group and drug combination group. During treatment, no side effect and adverse drug reaction were observed. CONCLUSIONS： Bifid tiple viable markedly improves the diarrhea after smoke abatement, which is wo thy of generalization and application. There is no synergism of therapeutic effects of berberine and bifid tiple viable