注射用硫酸头孢噻利与替硝唑注射液的配伍稳定性考察

目的：考察室温下注射用硫酸头孢噻利与替硝唑氯化钠注射液配伍后的稳定性。方法：模拟临床用药浓度，采用高效液相色谱（HPLC）法测定配伍液0～8h内硫酸头孢噻利和替硝唑的含量变化，并考察配伍液外观、pH值、微粒数量变化。结果：注射用硫酸头孢噻利与替硝唑氯化钠注射液配伍后，8h内二者含量变化不大，溶液澄清但颜色逐渐加深，配伍液pH值变化不大，不溶性微粒数符合《中国药典》（2010年版）规定。结论：注射用硫酸头孢噻利与替硝唑氯化钠注射液可配伍使用，但应在4h内输注完。

Compatible Stability of Cefoselis Sulfate for Injection with Tinidazole Injection

OBJECTIVE： To investigate the compatible stability of Cefoselis sulfate for injection with Tinidazole sodium chol- oride injection at room temperature. METHODS： For clinical dose, the contents of cefoselis sulfate and tinidazole within 8h were determined by HPLC ; the appearance and pH values of mixture and the number of particles were investigated. RESULTS ： The contents of cefoselis sulfate and tinidazole were stable within 8 h after mixing. The mixture was clear, but the color gradually deepened. The pH values of the mixture were also stable. The number of insolubility particles was also consistent with Chinese Pharmacopeia（2010 edition）. CONCLUSIONS： Cefoselis sulfate for injection can be mixed with Tinidazole sodium chloride injection but should be used up within 4 h.