血必净注射液联合左氧氟沙星治疗泌尿系统感染的临床观察

目的：观察血必净注射液联合左氧氟沙星治疗泌尿系统感染的临床疗效及安全性。方法：选择78例泌尿系统感染患者，按随机数字表法分为对照组（38例）和治疗组（40例）。对照组患者给予左氧氟沙星氯化钠注射液300mg静脉滴注，bid；治疗组患者在对照组患者治疗的基础上给予血必净注射液50ml加入0．9％氯化钠注射液100ml中静脉滴注，30-40min内滴完，bid。两组患者均治疗7d。观察两组患者治疗前、后临床症状及体征的变化，24h尿常规，肝、肾功能，血常规及不良反应发生情况。结果：治疗后，治疗组患者总有效率（82．5％）显著高于对照组（63．2％），两组比较差异有统计学意义（P〈0．05）；两组患者治疗后尿常规各项指标较治疗前均显著改善，差异有统计学意义（P〈0．05），但组间比较差异无统计学意义（P〉0．05）；两组患者治疗后临床症状及体征较治疗前均显著改善，且治疗组患者临床症状及体征较对照组患者改善更显著，两组比较差异有统计学意义（P〈0．05）。两组患者不良反应发生率比较差异无统计学意义（P〉0．05），且治疗期间两组患者肝、肾功能和血常规均无明显变化。结论：血必净注射液联合左氧氟沙星治疗泌尿系统感染，疗效及安全性均较好。

Clinical Observation of Xuebijing Injection Combined with Levofloxacin in the Treatment of Urinary Tract Infection

OBJECTIVE： To observe the clinical efficacy and safety of Xuebijing injection combined with Levofloxacin for urinary tract infection. METHODS： 78 patients with urinary tract infection were randomly divided into control group （38 cases） and treatment group （40 cases）. Control group was given Levofloxacin sodium chloride injection 300 mg, bid, intravenously; treatment group was given Xuebijing injection 50 ml added into 0.9% Sodium chloride injection 100 ml, bid, intravenously, within 30-40 min on the basis of control group. Treatment course of 2 groups lasted for 7 days. The changes of clinical symptom and signs were observed in 2 groups before and after treatment. The urine routine, hepatic and renal function, blood routine and ADR were observed in 2 groups before and after treatment. RESULTS： Total effective rate of treatment group （82.5%） was significantly higher than control group （63.2 % ） ; there was statistical significance （P〈 0.05）. The urine routine of both groups were improved significantly; there was statistical significance （P〈0.05）. There was no statistical significance between 2 groups after treatment （P〉 0.05）. Clinical symptom and signs of 2 groups were improved significantly; those of treatment group were improved significantly after treatment, compared with control group; there was statistical significance （P〈0.05）. There was no statistical significance in the incidence of ADR between 2 groups （P〉0.05）. No obvions charge was found in hepatic and renal function, blood routine of 2 groups during treatment. CONCLUSIONS： Xuebijing injection combined with Levofloxacin for urinary tract infections can promote therapeutic efficacy and show good safety.