地诺前列酮栓用于足月妊娠产妇引产的临床观察

目的：观察地诺前列酮栓用于足月妊娠产妇引产的临床疗效和安全性。方法：选择111例足月妊娠初产妇，按随机数字表法分为对照组（50例）和观察组（61例）。两组产妇均排尿后行外阴消毒，观察组产妇于阴道后穹隆处放置地诺前列酮栓1枚，卧床2h后可自由活动；对照组产妇给予催产素2．5u加入5％葡萄糖溶液500ml中静脉滴注，以8滴／min开始，根据宫颈收缩情况调节滴速至有效宫颈收缩（2～3次／10min），每次持续30S。观察两组产妇引产效果，分娩情况，产后出血量及分娩结果；记录所有新生儿情况；观察两组产妇不良反应发生情况。结果：观察组产妇总有效率显著高于对照组，两组比较差异有统计学意义（P〈0．01）；观察组产妇引产时间、总产程较对照组显著缩短，两组比较差异有统计学意义（P〈0．01），但两组产妇产后出血量比较差异无统计学意义（P〉0．05）；观察组产妇阴道分娩率显著高于对照组，剖宫产率显著低于对照组，两组比较差异均有统计学意义（P〈0．01）；两组新生儿情况和产妇不良反应发生率比较差异均无统计学意义（P〉0．05）。结论：地诺前列酮栓可安全用于足月妊娠产妇引产，不仅可以提高阴道分娩率，而且安全．洼较好。

Clinical Observation of Dinoprostone Suppository for Induction of Term Pregnancy

OBJECTIVE： To observe clinical efficacy and safety of Dinoprostone suppository for induction of term pregnancy. METHODS： 111 premiere were randomly divided into observation group （61 cases） and control group （50 cases）. 2 groups received vulvar disinfection after urinating. Observation group were treated with one piece of Dinoprostone suppository on posterior vaginal fornix; delivery woman could move freely after remaining in bed for 2 h. Control group was given intravenous dripping of oxytocin 2.5 u added into 5% glucose 500 ml at initial rate of 8 drops/rain. The dripping speed should be adjusted to effective value （2-3 times/10 min, lasting for 30 s each time） according to the situation of uterine contraction. The situation and results of labor induction and delivery were observed in 2 groups; The situation of neonate was recorded; the occurrence of ADR was observed in 2 groups. RESULTS： Total effective rate of observation group was significantly higher than that of control group; there was statistical significance （P〈0.01）. The induction time and delivery time of observation group were shortened significantly, compared with control group; there was statistical significance （P〈0.01）. There was no significant difference in postpartum hemorrhage between 2 groups （P〉0.05）. Compared with control group, normal labor rate of observation group was higher but cesarean section rate was significantly （lower than control group）; there was statistical significance （P〈0.01）. There were no statistical significance in the incidence of ADR and new born between 2 groups （P〉0.05）. CONCLUSIONS： Dinoprostone suppository is safe and effective for induction of term pregnancy and can improve normal labor rate and shows good safety.