胡蜂蜇伤患者炎症反应与发生心肾损伤的关系

目的 探讨胡蜂蜇伤患者炎症反应程度与患者心肾损伤的关系。方法 选取我院2018年6月—2021年10月收治的116例胡蜂蜇伤患者作为病例组，选取同期年龄、性别与之基本匹配的非胡蜂蜇伤志愿者120例作为对照组，对比两组的血清IL-6、IL-8水平；另按照患者是否发生全身炎症反应综合征(SIRS)进行分层分析各项炎症指标、心功能、肾功能指标差异，并分析炎症指标与心肾功能指标的相关性。结果 病例组患者的血清IL-6、IL-8,外周血WBC显著高于对照组，PLT低于对照组，差异具有统计学意义(P<0.05)。SIRS组和非SIRS组患者的年龄、身高、体重、性别、吸烟、饮酒情况比较，差异无统计学意义(P>0.05)。SIRS组患者的蜇伤针数多于非SIRS组，SIRS组患者的就诊时间较非SIRS组更长，SIRS组患者存在多部位蜇伤患者占比均高于非SIRS组，差异具有统计学意义(P<0.05)。SIRS组患者的血清IL-6、IL-8,外周血WBC显著高于非SIRS组，PLT低于非SIRS组，差异具有统计学意义(P<0.05)。SIRS组患者的血清CK、CK-MB、AST、LD...

Study on the relationship between inflammatory reaction and heart and kidney injury in wasp sting patients

Objective To explore the relationship between the degree of inflammatory reaction and the heart and kidney injury in patients with wasp sting. Methods 116 wasp sting patients admitted to our hospital from June 2018 to October 2021 were selected as the case group, and 120 non-wasp sting volunteers who were basically matched in age and sex were selected as the control group. The levels of serum IL-6 and IL-8 were compared between the two groups, and the differences of inflammatory indexes, cardiac function and renal function were analyzed according to whether the patients developed systemic inflammatory response syndrome (SIRS). The correlation between inflammation index and cardiac and renal function index was analyzed.Results The levels of serum IL-6, IL-8 and peripheral blood WBC in the case group were significantly higher than those in the control group, and the PLT was lower than that in the control group, the difference was statistically significant (P<0.05). There was no significant difference in age, height, weight, sex, smoking and alcohol consumption between SIRS group and non-SIRS group (P>0.05). The number of stings in the SIRS group was more than that in the non-SIRS group. The patients in the SIRS group had a longer time to see a doctor than that in the non-SIRS group. The proportion of patients with multiple site stings in the SIRS group was higher than that in the non-SIRS group, and the difference was statistically significant (P<0.05). The levels of serum IL-6, IL-8 and peripheral blood WBC in SIRS group were significantly higher than those in non-SIRS group, and PLT was significantly lower than that in non-SIRS group (P<0.05). The levels of serum CK, CK-MB, AST, LDH, BUN, Scr and UA in patients with SIRS were significantly higher than those in patients without SIRS (P<0.05). The levels of serum IL-6, IL-8 and CK, CK-MB, AST, LDH, Scr and UA in SIRS patients stung by wasps were significantly positively correlated (P<0.05). Conclusion The serum levels of IL-6 and IL-8 in wasp sting patients are significantly higher, and the levels of IL-6 and IL-8 in patients with inflammatory response syndrome are more significantly higher, which is related to the myocardial and renal function damage in patients