Genetic characterization of Chikungunya virus in the Central African Republic |
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| Affiliation: | 1. Virology Department, Institut Pasteur de Bangui, Bangui, Central African Republic;2. Epidemiology and Physiopathology of Oncogenic Viruses Unit, Institut Pasteur, Paris, France;3. Laboratory for Urgent Responses to Biological Threats, Institut Pasteur, Paris, France;1. Kidney Transplant Unit, Hospital Universitário Walter Cantídio – Fortaleza, Ceará, Brazil;2. Liver Transplant Unit, Hospital Universitário Walter Cantídio – Fortaleza, Ceará, Brazil;3. Universidade Estadual do Ceará - Fortaleza, Ceará, Brazil;1. Division of Environmental Health Sciences, Kochi Medical School, Kochi University, Oko, Nankoku 783-8505, Japan;2. Division of Cell Biology, Department of Preclinical Sciences, Faculty of Medicine, Thammasat University, Rangsit Campus, Pathum Thani 12120, Thailand;3. Department of Clinical Laboratory Medicine, Kochi Medical School, Kochi University, Oko, Nankoku 783-8505, Japan;4. Department of Public Health, Faculty of Science and Technology, Phetchabun Rajabhat University, Phetchabun 67000, Thailand;5. Liver Fluke and Cholangiocarcinoma Research Center (LFCRC), Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand;6. Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand;7. Imperial College London, Faculty of Medicine, St Mary’s Campus, South Wharf Street, London W2 1NY, United Kingdom;8. Institute of Zoology 1: Ecology and Parasitology, University of Karlsruhe, Kornblumen Strasse 13, Karlsruhe, Germany;9. Walai Rukhavej Botanical Research Institute (WRBRI), Mahasarakham University, Maha Sarakham 44150, Thailand;10. Cholangiocarcinoma Screening and Care Program, Faculty of Medicine, Khon Kaen Univeristy, Khon Kaen 40002, Thailand |
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| Abstract: | Chikungunya virus (CHIKV) is an alphavirus transmitted by the bite of mosquito vectors. Over the past 10 years, the virus has gained mutations that enhance its transmissibility by the Aedes albopictus vector, resulting in massive outbreaks in the Indian Ocean, Asia and Central Africa. Recent introduction of competent A. albopictus vectors into the Central African Republic (CAR) pose a threat of a Chikungunya fever (CHIKF) epidemic in this region. We undertook this study to assess the genetic diversity and background of CHIKV strains isolated in the CAR between 1975 and 1984 and also to estimate the ability of local strains to adapt to A. albopictus. Our results suggest that, local CHIKV strains have a genetic background compatible with quick adaptation to A. albopictus, as previously observed in other Central African countries.Intense surveillance of the human and vector populations is necessary to prevent or anticipate the emergence of a massive CHIKF epidemic in the CAR. |
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| Keywords: | Chikungunya virus Genetic variability Central African Republic |
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