The attentional networks in benign epilepsy with centrotemporal spikes |
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| Institution: | 1. The First Affiliated Hospital of Anhui Medical University, PR China;2. Department of Neurology, Anhui Provincial Children''s Hospital, Anhui Medical University, PR China;3. Laboratory of Neuroimaging, Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1230, New York, NY 10029, USA;1. Melbourne School of Psychological Sciences, The University of Melbourne, Victoria, Australia;2. Comprehensive Epilepsy Program, Austin Health, Victoria, Australia;3. Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, NIHR University College London Hospitals Biomedical Research Centre, London, UK;1. Department of Life, Health and Environmental Sciences, University of L''Aquila, Italy;2. Department of Mental Health, ASL1, L''Aquila, Italy;3. Clinical Neurophysiology Unit, ASL1, San Salvatore Hospital, L''Aquila, Italy;1. Department of Psychology, Macquarie University, NSW, Australia;2. Department of Medical Psychology, Westmead Hospital, NSW, Australia;3. Sydney Medical School, University of Sydney, NSW, Australia;4. Departments of Neurology, Westmead Hospital and The Children''s Hospital at Westmead, NSW, Australia;5. Department of Molecular Imaging, Royal Prince Alfred Hospital, NSW, Australia;6. Institute of Neurological Sciences, Prince of Wales Hospital, NSW, Australia;7. Faculty of Medicine, University of New South Wales, NSW, Australia;1. Department of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA;2. Department of Psychology, Rosalind Franklin School of Medicine and Science, North Chicago, IL, USA;1. Department of Biomedical, Metabolic and Neural Science, University of Modena and Reggio Emilia, Modena, Italy;2. Mental Health Unit, National Centre of Epidemiology, Surveillance and Health Promotion, Italian National Institute of Health, Italy;3. IRCCS Neuromed, Pozzilli, IS, Italy |
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| Abstract: | Benign epilepsy affecting children with normal mental development often occurs at a particular age, responds well to medication, and could be resolved completely by puberty. Although several studies have shown neuropsychological disabilities of children with benign epilepsy with centrotemporal spikes (BECTS), there is no clear evidence about the impairment of attentional systems and the comorbidity of attentional problems. Our research was based on the attention network model and assessed the characteristics of three anatomically defined subnetworks (alerting, orienting, and executive control) of 90 children with BECTS and 90 healthy children. All the subjects enrolled in the study participated in the attention network test (ANT) with assessment of both the reaction time (RT) and accuracy of the test. The results indicated that the performance of healthy controls was significantly better in orienting of attentional system (P < 0.001) and the accuracy of attention network test (P < 0.001), compared with that of children affected by BECTS. The grand mean effect (higher score worse) was significantly higher (P < 0.001) in the patient group than that in the control group. The multiple linear regression analysis revealed a positive correlation between the age of onset and the accuracy of attention network test results, and a negative correlation between the age of onset and the results of grand mean effect. A negative correlation was observed between spike index (SI) of the non-REM sleep stage and the accuracy of attention network test results. We found no relationship between the grand mean effect and clinical factors such as gender, duration of clinical course, duration of seizures, total number of seizures, severity of seizures (seizure frequency), hemispheric lateralization of electroencephalograph (EEG), and the awake SI. Furthermore, no relationship was observed between the clinical factors and the accuracy of the test results. The findings showed that BECTS is associated with impaired attentional networks, and impairments are greater at younger ages of onset. |
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