Patterns of verbal learning and memory in children with intractable temporal lobe or frontal lobe epilepsy |
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| Affiliation: | 1. Department of Psychology, Hospital for Sick Children, 555 University Ave., Toronto, ON M5G 1X8, Canada;2. Department of Psychology, York University, 4700 Keele St., Toronto, ON M3J 1P3, Canada;3. Department of Psychology, University of Toronto, 3359 Mississauga Rd., Mississauga, ON L5L 1C6, Canada;1. Melbourne School of Psychological Sciences, The University of Melbourne, Victoria, Australia;2. Comprehensive Epilepsy Program, Austin Health, Victoria, Australia;3. Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, NIHR University College London Hospitals Biomedical Research Centre, London, UK;1. Owensboro Medical Health System Neurology, USA;2. Department of Neurology, Vanderbilt University, Nashville, TN, USA;3. Hamad Medical Corporation, Doha, Qatar;1. Adiyaman University Training and Research Hospital, Neurology, Adiyaman, Turkey;2. Adiyaman University Training and Research Hospital, Radiology, Adiyaman, Turkey;3. Tekirdag Goverment Hospital, Child Psychiatry, Tekirdag, Turkey;4. Adiyaman University Training and Research Hospital, Physical Medicine and Rehabilitation, Adiyaman, Turkey;5. Adiyaman University Training and Research Hospital, Psychology, Adiyaman, Turkey;1. Department of Pediatric Psychology, CHOC Children''s Hospital, USA;2. Department of Neurology, University of California Irvine, USA;3. Neuroscience Institute, CHOC Children''s Hospital, USA;1. Australian Centre for Child Neuropsychology Studies, Murdoch Childrens Research Institute, Melbourne, Australia;2. RCH Mental Health, The Royal Children''s Hospital, Melbourne, Australia;3. School of Psychology and Psychiatry, Monash University, Victoria, Australia;4. Department of Neurology, The Royal Children''s Hospital, Melbourne, Australia;5. Psychology Department, Sunshine Hospital, Melbourne, Australia;6. School of Psychological Sciences, University of Melbourne, Melbourne, Australia;7. School of Psychology, University of Birmingham, UK;1. Department of Psychology, The Hospital for Sick Children, 555 University Ave, Toronto, ON M5G 1X8, Canada;2. Department of Psychology, University of Toronto Mississauga, Mississauga, Canada;3. Neurosciences and Mental Health Program, The Hospital for Sick Children, Toronto, Canada |
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| Abstract: | PurposeThe objective of this study was to provide a better understanding of the verbal learning and memory (VLM) patterns that might differentiate children with frontal lobe epilepsy (FLE) from children with temporal lobe epilepsy (TLE) and to examine the impact of variables thought to influence outcomes (seizure laterality, age at seizure onset, age at assessment, epilepsy duration, number of antiepileptic drugs).MethodsRetrospective analyses were carried out for children with intractable unilateral TLE (n = 100) and FLE (n = 27) who completed standardized measures of VLM entailing lists of single words or lists of word pairs.ResultsMean intelligent quotients and VLM scores on single words fell within the average range for both groups, whereas scores fell within the low average to borderline range on word pairs. No significant overall differences in VLM were found between the group with TLE and the group with FLE.Older age at assessment and older age at seizure onset were generally associated with better VLM in both groups but were related to better performance in a number of indices in the group with TLE and only fewer intrusions in the group with FLE.ConclusionsThe VLM profiles of children with TLE and FLE are generally similar. Older age at assessment and older age at seizure onset have a favorable impact on both groups but are related to better encoding, retrieval, and monitoring processes for the group with TLE and improved memory monitoring (i.e., as indicated by fewer intrusions) in the group with FLE. |
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