Acrp30生物学功能及调控的研究进展

Acrp30是脂肪来源的血浆蛋白，其生理学功能包括调节糖、脂代谢，提高胰岛素敏感性，抗动脉粥样硬化等。新近的研究表明，Acrp30有抗炎保肝的效果，有可能成为一种新的肝病治疗药物。Acrp30表达调控是与代谢相关的多种因素综合作用的结果，其中肾脏在Acrp30生物降解和清除中起重要作用，但目前Acrp30在体内的作用机制还有待于进一步研究。

Advances in research on biological function and regulation of Acrp30

Acrp30 is an adipose-derived plasma protein. It has various biological functions such as regulating glucose and lipid metabolism, increasing insuli n sensitivity, antiatherosclerosis and so on. Hepatoprotective effects of Acrp30 have been observed recently, which indicated that it may be a novel agent for t he treatment of liver diseases. Various metabolism-associated factors participate in regulating the expression of Acrp30. The kidney seems to play an important role in Acrp30 biodegradation and/or elimination. However, the mechanism of function of Acrp30 in vivo remains to be elucidated.