Comparative study of intranasal midazolam and intravenous diazepam sedation for procedures and seizures

Objective To evaluate the safety and efficacy of intranasal midazolam for seizures and various procedures. Methods Prospective randomized study. Total 125 children of all ages of either sex, for seizure episode (n-76) and various invasive and non-invasive procedures (n-49) received either intranasal midazolam (0.2 mg/Kg) or intravenous diazepam (0.3 mg/Kg). Results Mean time from arrival at hospital to starting treatment was significantly shorter in midazolam group compared to diazepam group [2.34±0.90; minute vs 4.61±1.08 minute p<0.001]. Mean time to control seizures after arrival in hospital was significantly shorter in midazolam group compared to diazepam group [5.25±0.86 minute vs 6.51±1.06 minute p<0.001]. Conclusion Midazolam by the intranasal route provides safe and equally effective non-invasive method of sedation for procedures and seizures.