| 赛尼哌两剂疗法预防移植肾急性排斥反应的临床研究 |
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| 引用本文： | 张海燕,陈统清,孔耀中,黄英伟. 赛尼哌两剂疗法预防移植肾急性排斥反应的临床研究[J]. 中国临床保健杂志, 2004, 7(5): 351-353 |
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| 作者姓名： | 张海燕 陈统清 孔耀中 黄英伟 |
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| 作者单位： | 广东佛山市第一人民医院肾内科,510080;广东佛山市第一人民医院肾内科,510080;广东佛山市第一人民医院肾内科,510080;广东佛山市第一人民医院肾内科,510080 |
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| 基金项目： | 广东佛山市卫生局资助课题 (2 0 0 4 10 4 ) |
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| 摘 要： | 目的 研究赛尼哌对预防移植肾急性排斥反应 (AR)的有效性 ,并评估其安全性。方法 选择同期以环孢素 (CsA) +骁悉 (MMF) +强的松三联为基础抗排斥方案的肾移植患者 4 2例 ,分为治疗组 2 1例 ,对照组 2 1例。在治疗组术前及术后 14d分别静滴赛尼哌一个剂量 ,对照组以生理盐水为安慰剂 ,观察期为 6个月。结果 移植后 3个月和 6个月 ,治疗组AR的发生率比对照组显著降低 (P <0 0 5 ) ,首次发生AR的时间明显延迟。两组毒副作用的发生率差异无显著意义 (P >0 0 5 )。结论 赛尼哌可显著降低移植肾AR的发生 ,并且应用安全。
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| 关 键 词： | 肾移植 急性排斥反应 赛尼哌 |
| 文章编号： | 1672-6790(2004)05-0351-02 |
| 修稿时间： | 2004-07-20 |
Two doses regimen of zenapax in the prevention of acute renal allograft rejection |
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| ZHANG Haiyan,CHENG Tongqing,KONG Yaozhong,et al.. Two doses regimen of zenapax in the prevention of acute renal allograft rejection[J]. Chinese Journal of Clinical Healthcare, 2004, 7(5): 351-353 |
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| Authors: | ZHANG Haiyan CHENG Tongqing KONG Yaozhong et al. |
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| Abstract: | Objective To investigate the effect of zenapax on the prevention of acute rejection(AR) in renal transplantation recipients.Methods 42 cases were randomized to be divided into 2 groups:zenapax group(n=21) and placebo control group(n=21).One dose zenapax was given in pre-transplantation 24h and post-transplantation 14 days separately.Follow-up lasted for 6 months.Results The percentage of AR episodes was significantly decreased in 6 months follow-up in zenapax group. The time of first AR was delayed compared to control group.No significant difference in adverse events was observed between two groups.4Conclusion It suggests that zenapax treatment could prevent AR in renal transplantation recipients without obvious side-effects. |
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| Keywords: | Renal transplantation Acute rejection Zenapax |
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