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The pharmacokinetics and pharmacodynamics of bumetanide in normal subjects |
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| Authors: | Laurence A. Marcantonio William H. R. Auld Graham G. Skellern Christine A. Howes W. Ronald Murdoch Rameshwar Purohit |
| Affiliation: | (1) Department of Clinical Biochemistry, North Ayrshire District General Hospital, KA2 0BE Kilmarnock, Ayrshire, UK;(2) Drug Metabolism Unit, Department of Pharmacy, University of Strathclyde, G11XW Glasgow, UK;(3) Forensic Science Unit, Department of Pharmacy, University of Strathclyde, G11XW Glasgow, UK;(4) Department of Medicine, Heathfield Hospital, Ayr, UK |
| Abstract: | The pharmacokinetics and pharmacodynamics of bumetanide (1 mg) administered either orally or intravenously were studied in a group of normal subjects using high-pressure liquid chromatography. A two-compartment model adequately fitted the intravenous data. Renal clearance (85 ml min–1 contributed 65% to the total elimination of bumetanide irrespective of whether a model-dependent or model-independent method was used. Oral administration of bumetanide elicited a greater and a more prolonged pharmacological response than did intravenous bumetanide. An attempt is made to relate the pharmacokinetics of the drug to its pharmacodynamics. |
| Keywords: | diuretic bumetanide pharmacokinetics pharmacodynamics normals |
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