| S系统及时序布尔网络模型构建鼠疫耶尔森菌基因调控网络的初步研究 |
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| 引用本文： | 江凌晓,江凌云.S系统及时序布尔网络模型构建鼠疫耶尔森菌基因调控网络的初步研究[J].热带医学杂志,2011,11(9):1088-1090. |
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| 作者姓名： | 江凌晓 江凌云 |
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| 作者单位： | 1. 南方医科大学珠江医院医学检验中心,广东广州,510282
2. 广州市商贸职业学校电子商务系,广东广州,510163 |
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| 基金项目： | 广东省自然科学基金(06301194); 国家重点实验室开放课题(200506) |
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| 摘 要： | 目的应用S幂率系统构建鼠疫耶尔森菌小尺度基因调控网络。方法收集鼠疫耶尔森菌基因时间序列表达数据,数据经预处理后,分别用布尔网络模型和S幂率系统网络模型构建小尺度基因调控网络,并对两个网络结构进行比较。结果应用布尔网络模型构建的小尺度基因调控网络中存在2种基因调控模式,而应用S幂率系统网络模型构建的小尺度基因调控网络中存在4种基因调控模式。结论 S幂率系统可用于构建基因调控网络模型。
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| 关 键 词： | 鼠疫耶尔森菌 基因调控网络 S系统 |
Preliminary study on the construction of gene regulatory network of Yersinia pestis based on temporal Boolean network and S-system |
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| JIANG Ling-xiao,JIANG Ling-yun.Preliminary study on the construction of gene regulatory network of Yersinia pestis based on temporal Boolean network and S-system[J].Journal Of Tropical Medicine,2011,11(9):1088-1090. |
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| Authors: | JIANG Ling-xiao JIANG Ling-yun |
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| Institution: | JIANG Ling-xiao1,JIANG Ling-yun2(1.Center of Clinical Laboratory,Zhujiang Hospital,Guangzhou 510282,2.Department of E-Commerce,Guangzhou Trade Vocational School,Guangzhou 510163,China) |
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| Abstract: | Objective To construct a gene regulatory network of Yersinia pestis based on S-system.Methods Collecting time series gene expression data of Yersinia pestis,and to construct a gene regulatory network of Yersinia pestis based on temporal Boolean network and S-system,respectively.Results There were 2 gene regulatory patterns in the temporal Boolean network model and 4 patterns in the S-system network model.Conclusion S-system should be the model for the gene regulatory network construction. |
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| Keywords: | Yersinia pestis gene regulatory network S-system |
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