3种用药方案治疗幽门螺杆菌感染的成本-效果分析

目的:评价3种用药方案治疗幽门螺杆菌(Hp)感染的成本-效果。方法:441例Hp感染的消化性溃疡患者随机分为3组,分别服用雷贝拉唑+克拉霉素+阿莫西林(A组)、奥美拉唑+克拉霉素+替硝唑(B组)、奥美拉唑+克拉霉素+阿莫西林(C组),各组疗程均为1周,观察疗效并进行成本-效果分析。结果:A、B、C组成本分别为325.04、221.30、211.64元,Hp根除率分别为92.2%、89.2%、79.1%,成本-效果比分别为352.54、248.09、267.56;A、B方案相对于C方案的增量成本-效果比分别为865.65、95.64。结论:B方案治疗幽门螺杆菌感染较为经济、合理。

Cost-Effectiveness Analysis on Three Therapeutic Schemes in the Treatment of Helicobacter Pylori Infection

OBJECTIVE:To evaluate the cost-effectiveness of three therapeutic schemes in the treatment of helicobacter pylori(Hp)infection.METHODS:A total of 441 cases with Hp infection were randomly divided into 3 groups:Group A was assigned to receive Rabeprazole clarithromycin Amoxicillin;Group B to receive Omepazole clarithromycin Timidazole,and Group C to receive Omepazole clarithromycin Amoxicillin.The curative effects of the 3 groups after treatment for 1wk were compared and the cost-effectiveness analysis was conducted as well.RESULTS:The costs for the 3 schemes were 325.04 yuan,221.30 yuan and 211.64 yuan,respectively;the Hp eradication rates of the three were 92.2%,89.2% and 79.1%,respectively;the cost-effectiveness ratios were 352.54,248.09 and 267.56 respectively;the increatmental cost-effectiveness ratios of Groups A and B were 865.65 and 95.64,respectively as against Group C.CONCLUSION:Group B is more economical and reasonable in the treatment of Hp infection.