自制动力散预防胆囊结石形成的实验研究

为探讨中药动力散预防胆囊结石的机理，选用家兔37只，随机分为3组。对照组（n=13）给予基础饲料；高胆固醇组（n=14）给予含1．2％胆固醇的高胆固醇饲料；高胆固醇十动力散组（n=10）给予高胆固醇饲料加能促进胆囊收缩的中药动力散，分笼饲养4周后，对胆囊成石情况和胆囊管阻力等进行观察与检测。结果发现，高胆固醇组12／14只形成结石，高胆固醇十动力散组2／10只形成结石，后者动物胆囊排空率较高胆固醇组显著增加，胆汁中粘蛋白浓度和胆囊管阻力则明显降低。表明动力散能通过促进胆囊收缩而降低胆汁中粘蛋白含量，降低胆囊管阻力，促进胆囊排空，有利于减少胆囊结石形成。

EXPERIMENT OF STUDY OF DONG LI SAN ON GALLSTONE PREVENTION

Thirty seven rabbits were randomly divided into three groups fed with different feeds,the basic feed group as a control, high cholesterol group (feed containing 1. 2% cholesterol) and highcholesterol feed added to Dong Li San which is a chinese medicine that can promote the contraction ofgallbladder. All animals were fed with the corresponding feeds for four weeks. The results showed that12 out of 14 rabbits in the high cholesterol group developed gallstone and 2 of 10 rabbits in the highcholesterol and Dong Li San feeding group had gallstone formation. The latter showed much higher emp-tying rate of gallbladder,lower level of mucin in the bile and much lower resistance to the cystic ductthan those of the former. The results suggest that Dong Li San can effectively prevent gallstone forma-tion by promoting gallbladder contraction,reducing mucin in bile,decreasing cystic duct resistance andpromoting the emptying capacity of gallbladder.