长期应用培哚普利和氨氯地平逆转原发性高血压左心室肥厚的对比研究

目的 :对比研究长期应用培哚普利和氨氯地平逆转原发性高血压 (EH)伴左心室肥厚 (L VH)的作用。　　方法 :将 114例 EH伴 L VH的患者分为培哚普利组 (n=5 8)和氨氯地平组 (n=5 6 ) ,于服药前及服药后 6、12、36个月分别测定左心室舒张末内径、舒张期室间隔厚度、左心室后壁厚度、左心室射血分数、心排血量、A/ E峰值。　　结果 :两组治疗前后比较左心室射血分数、心排血量均无变化 ,而 A/ E峰值则明显降低 ;左心室重量指数、左心室舒张末内径、舒张期室间隔厚度、左心室后壁厚度在培哚普利组明显下降 ,而在氨氯地平组则无变化。　　结论 :培哚普利和氨氯地平均能明显改善左心室舒张功能 ,但仅培哚普利能明显减轻左心室肥厚。

Comparison Study of Long-Term Perindopril and Amlodipine on Left Ventricular Hypertrophy in Essential Hypertension

Objective:To compare the reversal effects of long term therapeutic effect of perindopril and amlodipine on left ventricular hypertrophy in essential hypertension(EH). Methods:One hundred and fourteen patients (perindopril group 58,amlodipine group 56)of EH with left ventricular hypertrophy (LVH) were divided randomizedly into two groups:perindopril and amlodipine groups,echocardiographic LV diastolic dimension (LVDd),LV systole dimension (LVSd),LV posterior wall dimension (LVPWd),LV ejection fraction (LVEF),carbon monoxide (CO),VA,VE,A/E ratio were measured before and after 6,12,36 months of treatment. Results:There is no change on LVEF and CO values before and after treatment of perindopril and amlodopine,nor difference between the two treated groups,but A/E ratio significantly decreased;LVMI,LVDd,IVSd,LVPWd were lower in perindopril group,but they did not change in amlodipine group. Conclusion:Perindopril significantly decreased LVH.The effect of both drugs were similar in improvement of LV diastolic function with EH.