多囊卵巢综合征合并胰岛素抵抗患者应用两种不同胰岛素增敏剂对糖代谢的影响

目的探究多囊卵巢综合征(PCOS)合并胰岛素抵抗患者应用两种不同胰岛素增敏剂对糖代谢的影响。方法选取2019年1月至2020年1月本院收治的PCOS合并胰岛素抵抗患者90例作为研究对象,按照随机数字表法分为二甲双胍组(n=45)和吡格列酮组(n=45)。二甲双胍组采用盐酸二甲双胍片治疗,吡格列酮组采用吡格列酮二甲双胍片治疗,比较两组治疗前后BMI、HOMA-IR、FINS和FBG等糖代谢水平,FSH、LH、E₂、T和LH/FSH等内分泌代谢水平。结果治疗前,两组BMI、HOMA-IR、FINS和FBG比较差异无统计学意义;治疗后,两组BMI均明显低于治疗前,吡格列酮组HOMA-IR和FINS均明显低于治疗前,差异均有统计学意义(P<0.05),二甲双胍组HOMA-IR、FINS和FBG与治疗前比较差异均无统计学意义;治疗后,吡格列酮组HOMA-IR和FINS明显低于二甲双胍组,差异有统计学意义(P<0.05),两组BMI和FBG比较差异无统计学意义。治疗前,两组FSH、LH、E₂、T和LH/FSH比较差异无统计学意义;治疗后,二甲...

Effect of two different insulin sensitizers on glucose metabolism in patients with polycystic ovary syndrome and insulin resistance

Objective To explore the effects of two different insulin sensitizers on glucose metabolism in patients with polycystic ovary syndrome (PCOS) and insulin resistance.Methods 90 patients with PCOS and insulin resistance admitted to our hospital from January 2019 to January2020 were selected as the research subjects.They were divided into metformin group (n=45) and pioglitazone group (n=45) according to the random number table method.The metformin group was treated with metformin hydrochloride tablets,and the pioglitazone group was treated with pioglitazone metformin tablets.The levels of glucose metabolism such as BMI,HOMA-IR,FINS and FBG,and endocrine metabolism such as FSH,LH,E₂,T and LH/FSH levels were compared between the two groups before and after treatment.Results Before treatment,there was no statistically significant difference in BMI,HOMA-IR,FINS and FBG between the two groups;after treatment,the BMI of the two groups were significantly lower than before treatment,while HOMA-IR and FINS in the pioglitazone group were significantly lower than before treatment,the difference was statistically significant (P<0.05).There was no significant difference in HOMA-IR,FINS and FBG between the metformin group and before treatment;after treatment,HOMA-IR and FINS in the pioglitazone group were significantly lower than those in the metformin group,and the difference was statistically significant (P<0.05),there was no statistically significant difference in BMI and FBG between the two groups.Before treatment,there was no significant difference in FSH,LH,E₂,T and LH/FSH between the two groups;after treatment,LH/FSH in the metformin group was significantly lower than before treatment (P<0.05),and there was no statistically significant difference in FSH,LH,E₂,and T compared with before treatment.FSH in the pioglitazone group was significantly higher than before treatment,E₂,T and LH/FSH were significantly lower than before treatment,and the difference was statistically significant (P<0.05),there was no significant difference in LH compared with before treatment;after treatment,the FSH of the pioglitazone group was significantly higher than that of the metformin group,and the T was significantly lower than that of the metformin group,the difference was statistically significant (P<0.05),there was no significant difference in LH,E₂and LH/FSH between the two groups.Conclusion The pioglitazone-metformin complex has the effects on protecting the function of vascular endothelial cells,anti-inflammatory,and improving blood lipid metabolism.At the same time,it can improve the symptoms of hirsutism and reduce body weight.