| 心磷脂外化在创伤性脑损伤中的研究进展 |
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| 引用本文： | 牛曼,王树洪,熊彬媛,姜兴宇,李玉林,刘婷婷,喻安永. 心磷脂外化在创伤性脑损伤中的研究进展[J]. 创伤外科杂志, 2022, 24(1): 69-73. DOI: 10.3969/j.issn.1009-4237.2022.01.000 |
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| 作者姓名： | 牛曼 王树洪 熊彬媛 姜兴宇 李玉林 刘婷婷 喻安永 |
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| 作者单位： | 遵义医科大学附属医院急诊科,贵州 遵义 563003 |
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| 基金项目： | 国家自然科学基金(82060245);省部共建协同创新中心项目(教科技厅函[2020]39号);贵州省科技计划项目([2019]5661、[2020]4Y149)。 |
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| 摘 要： | 创伤性脑损伤(TBI)造成严重的神经损伤,为社会和个人带来巨大经济负担,然而目前保护神经的有效治疗方法还比较缺乏,成为一个亟待解决的问题.线粒体特异性脂质-心磷脂(CL)对TBI的治疗作用在基础研究中显示出希望.本文围绕CL在神经细胞凋亡和线粒体自噬两方面的研究作一综述,重点介绍CL外化介导的线粒体自噬机制及其在脑损伤...
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| 关 键 词： | 创伤性脑损伤 心磷脂 细胞凋亡 线粒体自噬 |
Research progress of cardiolipin externalization in traumatic brain injury |
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| Niu Man,Wang Shuhong,Xiong Binyuan,Jiang Xingyu,Li Yulin,Liu Tingting,Yu Anyong. Research progress of cardiolipin externalization in traumatic brain injury[J]. Journal of Traumatic Surgery, 2022, 24(1): 69-73. DOI: 10.3969/j.issn.1009-4237.2022.01.000 |
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| Authors: | Niu Man Wang Shuhong Xiong Binyuan Jiang Xingyu Li Yulin Liu Tingting Yu Anyong |
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| Affiliation: | (Department of Emergency,Affiliated Hospital of Zunyi Medical University,Zunyi,Guizhou 563003,China) |
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| Abstract: | Traumatic brain injury(TBI)causes severe nerve injury and leads to a great burden to society and individuals.However,there is still a lack of effective neuroprotective treatments.At this time,the therapeutic effect of cardiolipin(CL),a mitochondria-specific lipid,on TBI has shown promise in basic studies.This review focuses on the research progress of CL in neuronal apoptosis and mitochondrial autophagy,focusing on the mechanism of CL externalization mediated mitochondrial autophagy and its role in brain injury.Further study of CL externalization,whether to restore normal mitochondrial function or promote mitochondria-induced apoptosis,is a potential strategy to improve treatment outcomes for TBI. |
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| Keywords: | traumatic brain injury cardiolipin cell apoptosis mitophagy |
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