高原地区牙周炎患者血清内脂素和瘦素水平的检测分析

目的 检测青海西宁地区牙周炎患者血清中内脂素(visfatin,VF)与瘦素(leptin,LP)的表达水平及其与牙周炎症指标的相关性.方法 随机选取2019年3—12月就诊的牙周炎患者50例(牙周炎组)和牙周健康者50例(健康对照组),由同一临床医师测量牙周炎症临床指标,包括探诊深度(probing depth,PD...

Serum visfatin and liptin levels and their associations with periodontal indexes in patients with periodontitis in plateau section

Objective To evaluate serum visfatin and leptin levels in patients with periodontitis living in Xining,Qinghai Province and to explore associations between serum visfatin and leptin levels and periodontal indexes.Methods Fifty patients with periodontitis(periodontitis group)and 50 healthy periodontal patients(healthy control group)were randomly selected from from March 2019 to December 2019.Demographic and clinical data including probing depth(PD),clinical attachment loss(CAL),gingival index(GI),sulcular bleeding index(SBI)were obtained by the same senior periodontist.Serum visfatin and leptin levels were measured by enzyme linked immunosorbent assay(ELISA)technique.Results Compared with the healthy control group,the level of serum VF was higher and the level of serum LP was lower in the periodontitis group(P<0.01),and these differences were statistically significant.The level of serum VF was positively correlated with PD(r=0.97,P<0.01)and CAL(r=0.94,P<0.01).The level of serum LP was negatively correlated with PD(r=-0.86,P<0.01)and CAL(r=-0.88,P<0.01).VF and LP were not correlated with GI and SBI(P>0.05).Conclusion In periodontitis patients living in plateau section,the level of serum VF and LP is closely related to the occurrence and development of periodontitis,which can reflect the degree of periodontal tissue damage to a certain extent.