Activation of D1 dopamine receptors stimulates the release of GABA in the basal ganglia of the rat |
| |
| Authors: | B Floran J Aceves A Sierra D Martinez-Fong |
| |
| Institution: | Department of Physiology, Biophysics and Neurosciences, Instituto Politecnico Nacional, Mexico, D.F. |
| |
| Abstract: | Here we have explored whether dopamine is able to modulate the release of gamma-aminobutyric acid (GABA) from striatal terminals to substantia nigra pars reticulata, entopeduncular nucleus, globus pallidus and caudate-putamen. The type of dopamine receptors involved was assessed by the blocking effect of either SCH 23390 (D1 antagonist) or (-)-sulpiride (D2 antagonist) of the dopamine effect. Dopamine stimulated (EC50 3.2 microM) the depolarization-induced release of 3H]GABA from slices isolated from all of the above mentioned nuclei. SCH 23390 dose-dependently blocked the dopamine stimulation, but (-)-sulpiride did not show any blocking effect. The results suggest that dopamine via D1 receptors modulates the release of GABA from striatal GABAergic terminals. |
| |
| Keywords: | |
|
|
