| 婴儿麻疹风疹减毒活疫苗联合免疫血清流行病学研究 |
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| 引用本文： | 王翠珍,张思敏,许国章,梅允淼,陈立群. 婴儿麻疹风疹减毒活疫苗联合免疫血清流行病学研究[J]. 传染病信息, 2000, 0(1) |
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| 作者姓名： | 王翠珍 张思敏 许国章 梅允淼 陈立群 |
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| 作者单位： | 宁波市卫生防疫站 315010 |
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| 摘 要： | 目的为探讨麻疹、风疹减毒活疫苗联合免疫的可行性。方法于1997年4～12月随机选择了342名8月龄婴儿进行研究,所有入选婴儿被随机分成3组,第1组105人,皮下接种BRD-Ⅱ株风疹疫苗;第2组105人,分别在左右臂同时皮下接种风疹疫苗和麻疹疫苗;第3组132人,皮下接种沪191株冻干麻疹疫苗。结果在免疫前,第1组与第2组的风疹血凝抑制(HI)抗体阳性率均为2.86％,几何平均滴度(GMI)均为1:1.06,第2组与第3组麻疹HI抗体阳性率分别为2.86％和5.30％,GMT为1:1.02和1:1.60。免疫后1个月,第1组与第2组的风疹HI抗体阳性率分别为98.10％和99.05％,GMT分别为1:144.15和1:148.99。两者的差异无显著的统计学意义。第2组与3组的麻疹HI抗体阳性率分别为99.05％和97.73％,GMT分别为1:35.10和1:32.85,两者的差异亦无显著的统计学意义。所有免疫的儿童均未发现局部和全身反应。结论研究结果表明:风疹、麻疹减毒活疫苗联合免疫可产生与常规免疫相同的免疫应答,风疹疫苗初免月龄定于8月龄与麻疹疫苗联合免疫是可行的。
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| 关 键 词： | 风疹疫苗 麻疹疫苗 联合免疫血 凝抑制抗体 |
Seroepidemiologic investigation among infants immunized with a combined vaccine containing attenuated measles and rubella |
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| Wang Cuizhen Zhang SiminXu GuozhangNingbo Epidemic PreventionStation of Zhejiang ProvinceNingbo. Seroepidemiologic investigation among infants immunized with a combined vaccine containing attenuated measles and rubella[J]. Infectious Disease Information, 2000, 0(1) |
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| Authors: | Wang Cuizhen Zhang SiminXu GuozhangNingbo Epidemic PreventionStation of Zhejiang ProvinceNingbo |
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| Affiliation: | Wang Cuizhen Zhang SiminXu GuozhangNingbo Epidemic PreventionStation of Zhejiang ProvinceNingbo 315000 |
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| Abstract: | Objective To investigate efficiency of immunization with a combined vaccine containing attenuated measles and rubella in infants. Methods 342 8-month-old infants were investigated for serum levels of hemagglutinin-inhibitory(HI) antibody of measles and rubella from April to December of 1997. The infants were randomly grouped into three: 105 babies were immunized with domestic BRD-2 strain of rubella vaccine, another 105 infants with a combined vaccine of measles and rubella, and 132 children with measles vaccine only. Results Before immunization, the prevalence and geometric mean (GMT) of HI antibody of measles were 2. 86% and 1: 1. 06 in group 1 and group 2; the prevalence and GMT of HI antibody of measles were 2. 86% and 1 : 1. 02 in group 2 and 5. 03% and 1: 1. 60 in group 3. After one month of immunization, 98. 1% and 99. 05% prevalence and 1 : 144. 15 and 1: 148. 99 GMT of HI antibody of rubella were found in group 1 and group 2, which had no statistic difference between the two groups. The prevalence and GMT of HI antibody of measles in group 2 and group 3 were 99. 05% and 97. 73% and 1 : 35. 1 and 1. 32. 85, respectively. There also was no statistic difference in the prevalence and GMT of measles antibody between the group 2 and group 3. Conclusion The results show that immunization with a combined vaccine of measles and rubella in 8-month-old infants is safe, effective and convenient. |
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| Keywords: | Rubella vaccine Measles vaccine Hemagglutination inhibition antibody |
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