西比灵、都可喜治疗椎-基底动脉供血不足的临床研究

目的 观察西比灵、都可喜治疗椎-基底动脉供血不足（VBI）的临床效果.方法 将138例椎-基底动脉供血不足患者随机分为两组：对照组（65例）采用丹参注射液20 ml加入低分子右旋糖酐500ml静脉滴注,每日1次;治疗组（73例）在对照组治疗的基础上加用西比灵5 mg,每晚睡前服,以及都可喜1片,每日2次.两组均治疗14日后观察疗效.结果 治疗组的治愈率、显效率分别是52%和41%,对照组的治愈率、显效率分别是34%和32%,两组比较差异有统计学意义（P〈0.01和P〈0.05）.经颅多普勒超声（TCD）检查发现两组经治疗后椎-基底动脉平均血流速度均明显增加,但治疗组明显优于对照组（P〈0.05）.结论 西比灵、都可喜联合低分子右旋糖酐及丹参注射液治疗VBI疗效显著,是一项值得临床推广的好方法.

Clinical observation of Flunarizine combined with Duxil treating with vertebra basilar insufficiency

Objective To observe the therapeutic effects of Flunarizine combined with Duxil on patients with vertebra basilar insufficiency. Methods 138 patients with vertebra basilar insufficiency were randomly divided into two groups. 65 patients in control group were treated by Dextran 40 injection 500ml with Danshen injection 20ml was given once everyday. 73 patients in treatment group were treated by Flunarizine and Duxil on the basis of giving the same treatment as the control group, Flunarizine 5mg was taken before sleep everynight, Duxil 1 tablet was taken twice everyday. The therapeutic effects were observed 14 days later.Results The healing rate and the obvious effective rate in treatment group were 52% and 41%,The healing rate and the obvious effective rate in control group were 34% and 32%.There were significant difference between treatment group and control group in the healing rate and the obvious effective rate( P<0.01 and P< 0.05 ). We had found by check with TCD ( Trans-cranial Doppler ) the average velocity of blood in vertebral basilar artery was obviously additional after the treatment in treatment group and control group, but the addition was more significant in the treatment group ( P< 0.05 ).Conclusions Flunarizine and Duxil combined with Dextran 40 and Danshen injection have an obvious therapeutic effect on vertebra basilar insufficiency. And it is a good method and is worthy to popularizie clinically.