甘丙素在急性心肌梗塞发病中的临床意义

测定31例急性心肌梗塞(AMI)患者血浆甘丙素(GAL)的放免活性,结果提示AMI患者急性期各次血浆GAL水平明显高于对照组.伴高血压、糖尿病和心功能不全者升高更显著.GAL和内皮素(ET)、血糖水平均呈正相关.实验性心肌梗塞大鼠血浆GAL、血清肌酸激酶(CK).CK同功酶(CK-MB)、丙二醛(MDA)含量亦明显高于对照大鼠.用GAL抗血清治疗心梗大鼠,减少坏死面积45.4%和缩小了梗塞范围47.1%,血浆GAL水平明显降低,血清CK、CK-MB、MDA活性有所抑制,提示早期阻断GAL的生物学效应,对防治AMI有重要意义.实验还发现牛磺酸对GAL亦有拮抗效用,显示牛磺酸有心肌细胞保护作用.

The clinical significance of galanin in the pathogenesis of acute myocardial infarction

The level of plasma galanin (GAL) wsa studied in 31 cases of acute myocardial infarction (AMI) by radioimmunoassay. The results showed that the plasma GAL level in the AMI group was significantly higher than that in the control group (P<0.01~0.001). In the group of AMI with hypertension ,diabetes and heart failure, the plasma GAL level increased more obviously .It was discoveredthat the plasma GAL level was positively . correlated with the plasma endothelin (ET) level, and alsowitn, content of blood sugar.The effect of GAL-antiserum on myocardial infarction(M1)was investigated on infarct model produced by ligature of left anterior descending coronary artery in rats. The results showed that the plasmalevel of GAL,CK,CK-MB and MDA elevated significantly in rats with MI,GAL-antiserum administration could reduce infarct size by 47.1% and decrease the plasma activity of CK,CK-MB and MDA. It issuggested that GAI. is an important factor in the pathogenesis of MI. It was also found that taurine antagonized markedly the effects of GAL which suggest that taurine may exert protective actions upon myocardial cells.