PPARγ激动剂罗格列酮对糖尿病大鼠心肌细胞超微结构的影响

目的:探讨罗格列酮对链尿佐菌类(STZ)糖尿病大鼠心肌超微结构改变的影响。方法:将48只雄性W istar大鼠随机分为正常对照组(C组)、糖尿病组(T组)利罗格列酮干预组(R组),分别于实验8周和12周检测血糖、血清C肽水平、心重指数和心肌细胞表面积,留取大鼠的左心室组织块行透射电镜扫描,观察心肌超微结构的改变。结果:与同期正常对照组相比,T组和R组心肌细胞中线粒体肿胀、变性,肌原纤维灶性溶解、变性,心肌纤维排列不整齐、断裂及收缩带形成;T组随时间进展病情加重,而R组心肌病变较R组轻,且随疗程进展病变明显减轻。讨论:罗格列酮作为PPARγ激动剂,具有抗炎、保护心肌的降糖外作用。

Effect of rosiglitazone on myocardial ultrastructure of STZ diabetic rats

Objective:To investigate the mechanism of heart protective effect of rosiglitazone on diabetic rat heart.Methods:Forty-eight male rats were randomly divided into normal control group(C),diabetic rat group(T)and rosiglitazone treatment group(R).After 8 weeks and 12 weeks,transmission electron microscope were used to examine the myocardial ultrastructure of the rats.And blood glucose,weight,index of heart weight,area of heart cell and C peptide in the blood were measured at the same time.Results:Compared with group C,myocardial mitochondrion were swelled and degenerationed,myofibril were focally dissolved degeneration myocardial fibers arranged irregularly,and fractured in group T and R,pathological changes were aggravated in group T,myocardial pathological changes were alleviated in group R,and reduces obviously along with the treatment course progress.Conclusion:Rosiglitazone may play a protective role in the heart of STZ diabetic rats.