肝素在预防过敏性紫癜患儿肾损害中的应用

目的:探讨肝素在预防过敏性紫癜患儿肾损害中的应用。方法:将我科2003年5月～2010年5月间收治的68例过敏性紫癜患儿随机分为两组,肝素治疗组34例,对照组34例,对照组予以常规基础治疗,肝素治疗组在常规治疗基础的同时加用低分子肝素钙注射液100U/kg,皮下注射,每日1次,连用2周,观察两组过敏性紫癜性肾炎及不良反应发生情况。结果:所有病例治疗后随访时间3个月以上,肝素治疗组发生肾炎2例(5.9%);对照组发生肾炎7例(20.6%),两组患儿肾炎发生率差异具有统计学意义(χ2=6.635,P<0.05),肾脏损害程度差异无统计学意义(χ2=4.605,P>0.05)。结论:应用肝素能预防或减少紫癜性肾炎的发生,具有显著的肾脏保护作用。

Clinical investigation of heparin for prevention children's renal damage caused by anaphylactoid purpura

Objective： To investigate the clinical effects of heparin for prevention of children′s renal damage caused by allergic purpura.Methods： Sixty-eight children with allergic purpura were randomly divided into treatment group and control group with 34 cases in each group.Both groups were treated with routine therapy,while the treatment group was also given injection of heparin at 100 u/Kg·d once per day for 2 consecutive weeks.Renal damage caused by anaphylactoid purpura was observed.Results： According to 3-month follow up,2（5.9%） and 7（20.6%） cases of nephritis caused by anaphylactoid purpura was observed in the treatment and control group,respectively,showing significant difference between the two groups（χ^2=6.635,P〈0.05）.Whereas,there were no significant differences between two groups in the degree of renal damage（χ^2=4.605,P〈0.05）.Conclusions： Heparin can effectively reduce the incidence of renal damage among children with allergic purpura,indicating its renal protection.