| 应激对大鼠自身免疫性脑脊髓炎模型的影响 |
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| 引用本文： | 林海谅,蒋小玲,商永华. 应激对大鼠自身免疫性脑脊髓炎模型的影响[J]. 海南医学院学报, 2011, 17(12): 1606-1608,1611. DOI: 46-1049/R.20111013.1032.007 |
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| 作者姓名： | 林海谅 蒋小玲 商永华 |
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| 作者单位： | 福建医科大学教学医院,福建省福州市第二医院神经内科,福建福州350007 |
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| 基金项目： | 福州市科技局科研基金项目(2008-S-90)~~ |
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| 摘 要： | 目的:观察应激刺激对实验性自身免疫性脑脊髓炎(EAE)SD大鼠细胞免疫的影响。方法:用豚鼠脊髓抗原免疫SD大鼠,制作SD大鼠EAE模型,并随机分为抗原免疫+应激处理组(A组)和单纯抗原免疫组(B组),观察两组大鼠EAE的发病率及病情严重程度。3周后处死SD大鼠,检测大鼠外周血CD4+、CD8+细胞比例和CD4+/CD8+比值。结果:接种豚鼠脊髓抗原的两组大鼠10d后开始发病,A组大鼠EAE发病率和病情严重评分均高于B组,差异有统计学意义(P<0.01)。A组外周血CD4+比例、CD4+/CD8+比值均低于B组,差异有统计学意义(P<0.05),CD8+细胞比例与B组相当,差异无统计学意义(P>0.05)。结论:应激刺激对EAE大鼠细胞免疫有抑制作用,促发并加重大鼠EAE病情。
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| 关 键 词： | 应激 实验性自身免疫性脑脊髓炎 淋巴细胞亚群 |
Influence of stress on SD rats model of experimental autoimmune encephalomyelitis |
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| LIN Hai-liang,JIANG Xiao-ling,SHANG Yong-hua. Influence of stress on SD rats model of experimental autoimmune encephalomyelitis[J]. Journal of Hainan Medical College, 2011, 17(12): 1606-1608,1611. DOI: 46-1049/R.20111013.1032.007 |
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| Authors: | LIN Hai-liang JIANG Xiao-ling SHANG Yong-hua |
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| Affiliation: | LIN Hai-liang,JIANG Xiao-ling,SHANG Yong-hua (Department of Neurology,the Second Hospital of Fuzhou,Teaching Hospital of Fujian Medical University,Fuzhou 350007,China) |
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| Abstract: | Objective: To investigate the influence of stress on rat model of experimental autoimmune encephalomyelitis(EAE).Methods: SD rat models of EAE were induced by injection of guinea-pig spinal cord homogenate,then randomly divided into stress group(group A) and simple homogenate group(group B),which were intervened with different methods.Severity and incidence of EAE of the two groups were observed and compared.Rats were sacrificed after 3 weeks,levels of CD4+,CD8+ cells,and CD4+/CD8+ were detected.Results: On... |
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| Keywords: | Stress Experimental autoimmune encephalomyelitis Lymphocyte subpopulation |
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