金纳多对轻中度血管性痴呆患者ApoE、Hcy及认知功能的影响

目的：探讨金纳多治疗轻中度血管性痴呆的疗效及安全性。方法：随机选取63例符合DSM-IV血管性痴呆(VD)诊断标准的轻中度VD患者（MMSE评分在10～26分之间）；分别于金纳多治疗前、治疗后6周及12周，用MMSE和ADL量表评定患者的认知功能、社会活动功能及日常生活能力；用药前及用药后12周，用TCD检测脑血流；用...

Influence of Ginaton on the ApoE,Hcy and cognitive function of patients with mild to moderate vascular dementia

Objective. To evaluate the efficacy and safety of Ginaton for patients with vascular de mentia. Methods.. A total of 63 cases that meet diagnostic criteria of DSM-IV vascular dementia （VD） （MMSE scores were between 10 to 26） were selected and treated with Ginaton. Before Ginaton treatment, 6 weeks and 12 weeks after the treatment, MMSE and ADL rating scale were used for evaluating patientsl cognitive function, social function and activities of daily living TCD detection of cerebral blood flow was conducted before and 12 weeks after the treatment; 12 weeks before and after the treatment, Blood routine test, urine routine test, liver function, kidney function, ECG were detected to evaluate the safety of Ginaton. Results. Twelve weeks after Ginaton treatment MMSE and ADL scores were significantly increased （P〈0.01） but ApoE, Hcy levels were decreased comparing with scores before the treatment, increased significantly （P all〈0. 01）; TCD results showed improvements in cerebral blood flow, no severe side effects were observed. Oonclusions： For patients with mild to moderate vascular dementia Ginaton treat- ment can improve cognitive function, social function and activities of daily living, reduced ApoE, Hcy lev els, effectively improve the patient＇s cerebral blood flow with great safety.