Umbilical cord blood immunology: relevance to stem cell transplantation |
| |
| Authors: | Lin Syh-Jae Yan Dah-Chin Lee Yen-Chang Hsiao Hsiu-Shan Lee Pei-Tzu Liang Yu-Wen Kuo Ming-Ling |
| |
| Affiliation: | (1) Division of Asthma, Allergy, and Rheumatology Department of Pediatrics, Chang Gung Children’s Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan, Republic of China;(2) Department of Obstetrics/Gynecology, Chang Gung Memorial Hospital, Taoyuan, Taiwan, Republic of China;(3) Department of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, 259, Wen-Hwa 1st Road, Kweishan, 333 Taoyuan, Taiwan, Republic of China; |
| |
| Abstract: | Because of its easier accessibility and less severe graft-versus-host disease, umbilical cord blood (UCB) has been increasingly used as an alternative to bone marrow for hematopoietic stem cell transplantation. Naiveté of UCB lymphocytes, however, results in delayed immune reconstitution and infection-related mortality in transplant recipients. This review updates the phenotypic and functional deficiencies of various immune cell populations in UCB compared with their adult counterparts and discusses clinical implications and possible therapeutic strategies to improve the outcome of stem cell transplantation. |
| |
| Keywords: | |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
