| 大豆异黄酮在低雌激素环境下对MMTV-erbB-2转基因小鼠的作用 |
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| 引用本文： | 蔡向前,张广平,李小卉,苏书娟,侯建峰,韩丹,介晓阳,冯笑山.大豆异黄酮在低雌激素环境下对MMTV-erbB-2转基因小鼠的作用[J].实用诊断与治疗杂志,2011,25(9). |
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| 作者姓名： | 蔡向前 张广平 李小卉 苏书娟 侯建峰 韩丹 介晓阳 冯笑山 |
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| 作者单位： | 河南科技大学第一附属医院研究生科,河南省洛阳市,471003 |
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| 摘 要： | 目的探讨大豆异黄酮在低雌激素环境下对MMTV-erbB-2转基因小鼠乳腺肿瘤发生、发展的影响。方法 MMTV-erbB-2转基因雌性小鼠90只,分为3组,每组30只。60只行卵巢摘除术使MMTV-erbB-2转基因小鼠体内形成低雌激素环境,分别使用含大豆异黄酮饲料(大豆异黄酮组)和普通饲料(普通饲料组)喂养。另30只为对照组,用普通饲料喂养。观察乳腺肿瘤的潜伏期及发生情况,用免疫组织化学法观察各组乳腺组织的雌激素受体、孕激素受体、增殖细胞核抗原的表达情况。结果大豆异黄酮组肿瘤潜伏期较其他2组明显缩短,增殖细胞核抗原表达水平较其他2组高(P<0.05)。3组雌激素受体、孕激素受体表达情况比较差异无统计学意义(P>0.05)。结论在低雌激素环境下,大豆异黄酮对MMTV-erbB-2转基因小鼠乳腺肿瘤的发生、发展起促进作用。
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| 关 键 词： | 乳腺肿瘤 MMTV-erbB-2转基因小鼠 去势手术 大豆异黄酮 雌激素受体 孕激素受体 增殖细胞核抗原 |
Effect of soybean isoflavones on MMTV-erbB-2 transgenic mice in the low estrogen environment |
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| CAI Xiang-qian,ZHANG Guang-ping,LI Xiao-hui,SU Shu-juan,HOU Jian-feng,HAN Dan,JIE Xiao-yang,FENG Xiao-sh,epartment of Postgraduate Students,the First Affiliated Hospital to Henan University of Science , Technology,Luoyang ,China.Effect of soybean isoflavones on MMTV-erbB-2 transgenic mice in the low estrogen environment[J].Journal of Practical Diagnosis and Therapy,2011,25(9). |
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| Authors: | CAI Xiang-qian ZHANG Guang-ping LI Xiao-hui SU Shu-juan HOU Jian-feng HAN Dan JIE Xiao-yang FENG Xiao-sh epartment of Postgraduate Students the First Affiliated Hospital to Henan University of Science Technology Luoyang China |
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| Institution: | CAI Xiang-qian,ZHANG Guang-ping,LI Xiao-hui,SU Shu-juan,HOU Jian-feng,HAN Dan,JIE Xiao-yang,FENG Xiao-shanDepartment of Postgraduate Students,the First Affiliated Hospital to Henan University of Science and Technology,Luoyang 471003,China |
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| Abstract: | Objective To study the influence of soybean isoflavones on occurrence and development of breast cancer in MMTV-erbB-2 transgenic mice.Methods In 90 female MMTV-erbB-2 transgenic mice,60 mice received surgical castration to create a low estrogen environment,in which 30 mice were fed with soy isoflavones diet(soy isoflavones group) and 30 mice were given normal diet.The other 30 mice receiving normal diet were as controls(control group).The latency and occurrence of breast tumor were observed.Immunohistochemi... |
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| Keywords: | Breast tumor MMTV-erbB-2 transgenic mice castration surgery soy isoflavone estrogen receptor progesterone receptor proliferating cell nuclear antigen |
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