| 川芎嗪注射液对子宫内膜异位症术后复发者治疗前、后血中VEGF的影响 |
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| 引用本文： | 卢玉婷,卢斋.川芎嗪注射液对子宫内膜异位症术后复发者治疗前、后血中VEGF的影响[J].海南医学院学报,2011,17(12):1628-1630. |
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| 作者姓名： | 卢玉婷 卢斋 |
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| 作者单位： | 1. 海南省琼海市中医院妇产科,海南琼海,571400
2. 海南省医学院附属医院妇产科,海南海口,570102 |
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| 基金项目： | 海南医学院科研基金资助学报项目(0020110447)~~ |
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| 摘 要： | 目的:探讨川芎嗪注射液对子宫内膜异位症术后复发者治疗前、后血中血管内皮生长因子(VEGF)的影响。方法:子宫内膜异位症术后复发患者60例,随机分为观察组和对照组,每组30例,正常体检妇女15例作为正常对照组。两组均给予米非司酮治疗,观察组加用川芎嗪注射液,连续用药12周,观察不良反应及血清E2水平。采用正常对照组体检时、两组患者均于治疗前及治疗后空腹抽血5mL,采用ELISA法定量检测VEGF。结果:观察组治疗子宫内膜异位症术后复发患者痛经、闭经改善优于对照组(P<0.01),使血清E2保持在卵泡期水平,副作用少。治疗后两组VEGF水平均下降,与治疗前有统计学差异(P<0.01),两组治疗后亦有显著性差异(P<0.01)。结论:川芎嗪注射液治疗子宫内膜异位症术后复发患者比单用米非司酮副作用少、安全性高,患者易于接受,且不出现雌激素缺乏症状,停药后排卵功能恢复快,月经复潮时间短,有利于早日受孕,VEGF水平可作为子宫内膜异位症术后复发的监测指标。
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| 关 键 词： | 复发性子宫内膜异位症 川芎嗪注射液 血管内皮生长因子 |
Effect of tetramethylpyrazine injection on VEGF expression in patients with postoperative recurrence of endometriosis |
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| LU Yu-ting,LU Zhai.Effect of tetramethylpyrazine injection on VEGF expression in patients with postoperative recurrence of endometriosis[J].Journal of Hainan Medical College,2011,17(12):1628-1630. |
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| Authors: | LU Yu-ting LU Zhai |
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| Institution: | LU Yu-ting1,LU Zhai2 (1.Department of Obstetrics and Gynecology,Qionghai Hospital of TCM,Qionghai 571400,China,2.Department of Obstetrics and Gynecology,Affiliated Hospital of Hainan Medical University,Haikou 570102,China) |
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| Abstract: | Objective: To explore tetramethylpyrazine injection on VEGF expression in patients with postoperative recurrence of endometriosis.Methods: A total of 60 patients with endometriosis recurrence were randomly divided into two groups: observation group and control group.Another 15 normal healthy women were selected as normal control group.All 60 patients were given mifepristone,while patients in observation group received tetramethylpyrazine injection.The treatment lasted for 12 weeks.The incidence of side effe... |
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| Keywords: | Recurrent endometriosis Tetramethylpyrazine injection vascular endothelial growth factor |
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