124例系统性红斑狼疮瘀热毒相关指标分析

目的:从临床研究探讨瘀热毒在系统性红斑狼疮发病中的重要作用。方法:对124例SLE临床病例瘀热毒相关症状、体征、实验室指标进行统计,并作相关性分析。结果:通过文献研究及临床研究,我们认为与瘀、热、毒相关的症状、体征有:面部皮疹/红斑、口腔溃疡、皮肤血管炎/血栓、甲周红斑/冻疮、雷诺现象、紫癜、发热、腹痛、烦躁、癫痫、肝/脾大、淋巴结肿等。实验室与瘀相关的指标有:血小板、凝血功能、D2聚体、血脂、抗心磷脂抗体等。与毒相关度的指标有:自身特异性相关抗体免疫指标,如IGG、C3、抗ENA等8项。与热相关的指标:如血沉、C反应蛋白等。药物治疗中,活血化瘀药、抗血小板/抗凝药、激素、抗生素是主要用药。结论:瘀热毒为系统性红斑狼疮的主要病理因素,热毒炽盛,深入营血,血络瘀阻,往往是系统性红斑狼疮活的基本病机,在本病的发病中起到了极其重要的作用,而瘀贯穿病程始终。

124 cases of systemic lupus erythematosus drug-related clinical cases stasis heat index analysis

Objective: Clinical studies of toxic heat stasis in the pathogenesis of systemic lupus erythematosus important role.Methods: The clinical cases of 124 patients with SLE stasis toxic heat-related symptoms,signs,laboratory indicators,statistics,and for correlation analysis.Results: The literature and clinical studies,we believe that with the stasis,heat,drugs-related symptoms and signs include: facial rash / erythema,oral ulcers,skin vasculitis / thrombosis,a week of erythema / frostbite,Raynaud's phenomenon,...