Isocoumarin derivatives from the sea squirt-derived fungus penicillium stoloniferum QY2-10 and the halotolerant fungus penicillium notatum B-52 |
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| Authors: | Zhi -Hong Xin Li -Tian Tian -jiao Zhu Wen -Liang Wang Lin Du Yu-chun Fang Qian -Qun Gu Wei -Ming Zhu |
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| Institution: | Key laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Food, Ocean University of China, Qingdao 266003, P R China. |
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| Abstract: | Two isocoumarin derivatives, stoloniferol A (1) and B (2), a known 5alpha, 8alpha-epidioxy-23-methyl-(22E, 24R)-ergosta-6, 22-dien-3beta-ol (3), and a known dihydrocitrinone (4) were isolated from the ethyl acetate extract of the sea squirt-derived fungus, Penicillium stoloniferum QY2-10, and a halophilic fungus, Penicillium notatum B-52, respectively. Their structures were elucidated by spectroscopic methods and optical rotation. The stereochemistry of 2 was determined on the basis of different NOE experiments and chemical transformation. Compound 3 showed cytotoxicity against P388 cells, with an IC50 value of 4.07 microM. |
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| Keywords: | Sea squirt-derived fungus Penicillium stoloniferum Halotolerant fungus Penicillium notatum Stoloniferol A and B |
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