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富半胱氨酸61与妇科肿瘤
引用本文:彭丽秀(综述),周昌菊(审校). 富半胱氨酸61与妇科肿瘤[J]. 国外医学:妇产科学分册, 2009, 0(5): 367-370
作者姓名:彭丽秀(综述)  周昌菊(审校)
作者单位:中南大学湘雅三医院,长沙410013
基金项目:湖南省科技厅资助项目(SK3047),湖南省卫生厅科研基金(C2007-009)
摘    要:富半胱氨酸61(Cyr61)是结缔组织生长因子(CCN)家族中具有代表性的成员,其富含半胱氨酸残基的分泌性肝素连接蛋白具有多模组结构。具有诱导血管生成,促进细胞黏附、转移及诱导多药耐药形成等效用,在子宫内膜癌、宫颈癌、卵巢癌、子宫肌瘤及子宫内膜异位症的发生发展中起重要作用。

关 键 词:富半胱氨酸61  结缔组织生长因子  肿瘤

The Cyr61 and Gynecological Tumor
Affiliation:PENG Li-xiu, ZHOU Chang-ju. (The Third Xiangya Hospital of Central South University, Changsha 410013,China)
Abstract:Cysteine-rich 61 (Cyr61) is a representive member in the connective tissue growth factor family. It has muhimode construction that possess the function of inducing angiogenesis and promoting cell adhesion and metastasize and rhultidrug resistance. Cyr61 plays an essential role in the 16athology of the endometrial cancer, cervical cancer, ovary cancer, uterus myoma and endometriosis.
Keywords:Cysteine-rieh 61  Connective tissue growth factor  Tumor
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