抗心磷脂抗体与缺血性卒中的研究进展

抗心磷脂抗体是抗磷脂抗体综合征的标志性抗体，与血栓形成和缺血性卒中密切相关。与抗磷脂抗体阴性的脑梗死患者相比，抗磷脂抗体阳性相关的脑梗死患者以青年女性居多，梗死部位多为多灶性，更容易复发，而且血管内膜内的斑块多为低回声斑块。抗心磷脂抗体与血脂、纤维蛋白原、肿瘤坏死因子水平均有一定相关性，并且抗心磷脂抗体滴度升高可能与患者自身免疫因素相关。在治疗上应以抗凝为主。

Study Advance in Anticardiolipin Antibody And Ischemic Cerebrovascular Disease

Anticardiolipin antibody is the typical antibody of antiphospholipid antibody syndrome, and it has much thing to do with thrombogenesis development and ischemic cerebrovascular disease. Compared with antiphospholipid antibody negative cerebral infarction patients with anticardiolipin antibody positive are prone to occure in young woman, cerebral infarction are multi-focus and attends to recurrence, plaques in tunica intima vasorum are apt to hypoechoic. Anticardiolipin antibody also has something to do with blood fat, fibrinogen and tumor necrosis factor, and the high titre of anticardiolipin antibody maybe concerned with the patient’s autoimmunity. Anticoagulation should be the chief therapy means.