Outcome of orthotopic liver transplantation in autoimmune hepatitis according to subtypes |
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| Authors: | Pierre Cattan Thierry Berney Filomena Conti Yvon Calmus J. C. Homberg Didier Houssin Olivier Soubrane |
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| Affiliation: | 1.Service de Chirurgie Digestive, H?pital Saint-Louis, 1 Avenue Claude Vellefaux, 75475 Paris Cedex?10, France,France;2.Service de Chirurgie, H?pital Cochin, 27 rue du Faubourg Saint-Jacques, 75679 Paris Cedex 14, France,France;3.Visceral and Transplant Surgery, Geneva University Hospital, 24 rue Micheli du Crest, 1205 Geneva, CP 1211, Switzerland,Switzerland;4.Laboratoire Central d'Immunologie et d'Hématologie, H?pital Saint-Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris, France,France |
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| Abstract: | The relevance of autoimmune hepatitis (AIH) classification for clinical purposes is controversial. We analyzed the outcome after orthotopic liver transplantation (OLT) of nine type I and seven type II AIH patients. Type II patients had a significantly higher incidence of cirrhosis at the time of diagnosis, more resistance to steroid therapy, and a higher Child-Pugh score at the time of OLT. OLT was performed in emergency in three type II patients and electively in all type I patients. Four type II and one type I patients died in the postoperative period. There was no difference regarding the incidence of post-OLT infection and rejection between the two types. No recurrence of AIH was observed. The 6-year actuarial survival rates for type I and type II patients were 76% and 43%, respectively. Type II AIH patients who have a poor response to medical therapy should be considered for OLT with a shortened delay. |
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| Keywords: | Autoimmune hepatitis Subtypes Liver transplantation |
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