男性不育患者精浆尿酸的检测及临床意义初探

目的 :检测男性不育患者精浆尿酸的含量 ,并探讨其与不育的关系。　方法 :2 0 0 3年 2～ 8月就诊的男性不育患者 1 6 3例 ,分为 4组 :梗阻性无精子症组 ,1 5例 ;非梗阻性无精子症组 ,36例 ;少精子症组 ,4 3例 ;弱精子症组 ,6 9例。 2 0例正常生育男性为正常对照组。上述各组均作精液参数分析及精浆尿酸含量的测定。　结果 :正常对照组精浆尿酸含量为 (396 .9± 5 3.1 ) μmol/L ,显著高于梗阻性无精子症组 (79.5± 1 8.1 ) μmol/L]、非梗阻性无精子症组(2 4 5 .8± 76 .5 ) μmol/L]、少精子症组 (2 6 2 .2± 79.2 ) μmol/L]和弱精子症组 (2 5 1 .4± 75 .4 ) μmol/L](P均 <0 .0 1 )。其中 ,梗阻性无精子症组精浆尿酸含量又显著低于其他各不育症组 (P均 <0 .0 1 ) ,其余各不育症组间精浆尿酸含量差异无显著性 (P >0 .0 5 )。　结论 :精浆中尿酸作为生殖系统中的一种重要抗氧化物 ,可能在男性生殖中具有一定意义。

Measurement of Uric Acid of Seminal Plasma in Fertile and Infertile Males

Objective: To measure uric acid of seminal plasma in fertile and infertile males. Methods: One hundred and sixty-three infertile males were divided into an obstructive azoospermic group (15 cases), a non-obstructive azoospermic group (36 cases), an oligozoospermic group (43 cases), and an asthenozoospermic group (69 cases). Twenty fertile males were included in the control group. Uric acid concentrations of seminal plasma in the fertile and infertile men were assessed by spectrophotometer, and sperm parameters were analyzed by computer-assisted semen analysis (CASA) system. Results: Uric acid concentration of seminal plasma in the control group was significantly higher than all the infertile groups (P< 0.01), and that of the obstructive azoospermic group significantly lower than the other infertile groups (P< 0.01), but no significant difference was observed among the other infertile groups (P> 0.05 ). Conclusion: Uric acid may play an important role in male reproduction because of its antioxidative property.