下尿路感染患者菌群分布及对磷霉素氨丁三醇散敏感度分析

目的 检测下尿路感染患者尿液中菌群分布及对磷霉素氨丁三醇散的敏感度。 方法 对2011年3~10月就诊于首都医科大学附属北京朝阳医院京西院区泌尿外科的80例表现为尿频、尿急、尿痛且尿常规提示脓尿的患者给予磷霉素氨丁三醇散治疗,治疗前留取清洁中段尿行细菌培养+药敏检查。对尿培养阴性患者治疗后1周行尿常规检查。对尿培养阳性患者治疗后1周行尿常规和尿培养检查,尿常规正常患者,停用磷霉素氨丁三醇散,1周后再次复查尿常规和尿培养检查;尿常规异常患者,继续口服磷霉素氨丁三醇散治疗1周,1周后再次复查尿常规和尿培养检查,间接分析磷霉素氨丁三醇散的敏感性。 结果 80例患者中,初次尿培养阳性72例,阴性8例,主要致病菌为大肠杆菌;72例下尿路感染患者中单纯性尿路感染50例,复杂性尿路感染22例;尿培养阳性者治疗1周后66例尿常规恢复正常,停用磷霉素氨丁三醇散,尿培养转阴,第3次尿常规和尿培养均为阴性;6例尿常规阳性患者继续口服磷霉素氨丁三醇散1周,尿培养均转阴,第3次尿常规和尿培养均为阴性;8例初次尿培养阴性者治疗1周后尿常规提示脓尿均消失。 结论 下尿路感染主要致病菌为大肠杆菌;磷霉素氨丁三醇散对革兰阳性菌和革兰阴性菌导致的下尿路感染均有效;对单纯性泌尿系感染和复杂性泌尿系感染均有良好的治疗效果,可以作为下尿路感染的经验用药。

Bacterial Distribution in Patients with Lower Urinary Tract Infection and the Sensitivity Analysis of Fosfomycin Tromethamine Bulk

Objective To study the urine flora distribution of the patients with lower urinary tract infection and the sensitivity of fosfomycin tromethamine bulk. Methods From March 2011 to October 2011, there were 80 patients with lower urinary tract infection who were treated with fosfomycin tromethamine bulk, via routine urinalysis and urinary culture to analysis the sensitivity of fosfomycin tromethamine bulk indirectly. Results Urine culture showed positive in 72 patients and urine culture negative in 8 patients. The common bacteria was Escherichia coli. 50 patients were uncomplicated, and 22 patients were complicated. Conclusion Fosfomycin tromethamine bulk was a valid drug to treat the lower urinary tract infection caused by gram-positive bacteria and gram-negative bacteria.