Coenzyme Q10 levels are low and may be associated with the inflammatory cascade in septic shock期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Coenzyme Q10 levels are low and may be associated with the inflammatory cascade in septic shock

Authors:	Michael W Donnino Michael N Cocchi Justin D Salciccioli Daniel Kim Ali B Naini Catherine Buettner Praveen Akuthota

Institution:	(1) Department of Emergency Medicine, Beth Israel Deaconess Medical Center, One Deaconess Road, West Clinical Center 2, Boston, MA 02215, USA;(2) Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, One Deaconess Road, Boston, MA 02215, USA;(3) Trauma/Surgical/Neurological Critical Care, Department of Anesthesia Critical Care, Beth Israel Deaconess Medical Center, One Deaconess Road, Boston, MA 02215, USA;(4) Department of Pathology and Cell Biology, Columbia University Medical Center, 630 West 168th Street, VC 15-208, New York, NY 10032, USA;(5) Division of General Medicine and Primary Care, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA;(6) Division of Allergy and Inflammation, Department of Medicine, Beth Israel Deaconess Medical Center, One Deaconess Road, Boston, MA 02215, USA

Abstract:	Introduction Mitochondrial dysfunction is associated with increased mortality in septic shock. Coenzyme Q10 (CoQ10) is a key cofactor in the mitochondrial respiratory chain, but whether CoQ10 is depleted in septic shock remains unknown. Moreover, statin therapy may decrease CoQ10 levels, but whether this occurs acutely remains unknown. We measured CoQ10 levels in septic shock patients enrolled in a randomized trial of simvastatin versus placebo.

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