| 阿魏洛芬的抗炎镇痛抗肿瘤作用 |
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| 引用本文： | 於传斌,吴华璞,葛敏,余晨光,赵明敏,陶明飞,隋治华,周淑兰,张琳萍,计志忠.阿魏洛芬的抗炎镇痛抗肿瘤作用[J].中国药理学通报,1989(5). |
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| 作者姓名： | 於传斌 吴华璞 葛敏 余晨光 赵明敏 陶明飞 隋治华 周淑兰 张琳萍 计志忠 |
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| 作者单位： | 蚌埠医学院药理教研室 沈阳药学院合成药物研究室 233003 |
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| 摘 要： | 肌注或腹腔注射阿魏洛芬对小鼠二甲苯耳廓炎症、大鼠角叉菜胶性足肿胀和急性胸膜炎以及巴豆油性肉芽肿均有明显抗炎作用(剂量范围在50～100mg/kg之间,并呈一定的量效关系。对小鼠醋酸扭体反应和光辐射性疼痛型亦显示较强的镇痛效应(100～300mg/kg)。其体外(艾氏腹水癌)体内(S180实体瘤)抑瘤结果表明对前者抑制率高于后者。提示该药可能成为较有希望的非甾体类抗炎抗肿瘤药物。
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| 关 键 词： | 阿魏洛芬 非甾体类抗炎药 抗炎 镇痛 抗肿瘤 |
ANTIINFLAMMATORY,ANALGESIC & ANTICANCER EFFECTS OF FERULOFEN |
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| Abstract: | Antiinf lammatory effects of Ferulofen ( FL ) were shown by im or ip on xylene-induced swellingof mice ear, carrageenin produced edema of hind paw in rats, and decreased volume of pleural exud- ate on carrageenin-induced acute pleurisy of rats, FL also inhibi-tied the proliferating granuloma by croton oil. The above dose r-ange in 50-100mg/kg im or ip which presented a good dose-effect relationship, FL also inhibited the mice writhing caused by H AC & tail-flick response to 1 light irradiation, suggesting its strong analgesic effect. In addition, its anticancer effect in vitro ( carcinoma of Ehlrich ascitis)was better than that in vivo ( Sl80 sarcoma) in mouse. So FL may be considered to be a promising new type of non-steroidal antiinflammatory & anticancer drug ,worthy of further reseaching & exploring in the future. |
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| Keywords: | Ferulofen Non-steroidal antiinflammatory drug Antiinflammatory Analgesic Anticancer |
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