低分子肝素钙联合辛伐他汀治疗不稳定型心绞痛疗效观察

目的观察采用低分子肝素钙联合辛伐他汀治疗不稳定型心绞痛(UA)的治疗效果。方法观察组除常规用药外,加用低分子肝素钙5 000 u,每12 h皮下注射1次,连用7~10 d,辛伐他汀20 mg,每晚顿服1次,连服8周。对照组除常规用药外,另加普通肝素100 mg加50 g.L-1葡萄糖溶液500 mL维持静脉滴注,维持激活全血凝固时间于正常值的1.5~2倍,连用7~10 d。检测2组治疗前后总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C),并评定疗效。结果观察组总有效率(92%)明显高于对照组(76%)(P<0.05)。2组治疗前TC、TG、LDL-C、HDL-C比较均无显著性差异(P>0.05);对照组治疗前后TC、TG、LDL-C、HDL-C比较均无显著性差异(P>0.05);观察组治疗后HDL-C明显升高,TC、LDL-C、TG均下降,与治疗前比较均有显著性差异(P<0.05),与对照组治疗后比较均有显著性差异(P<0.05)。结论采用低分子肝素钙联合辛伐他汀治疗UA效果明显,安全可靠。

Effect of low molecular weight heparin calcium and simvastatin on patients with unstable angina pectoris

Objective To observe the clinical effect of low molecular weight heparin combined with simvastatin on unstable angina（UA）. Methods The patients in observation group were treated with low-molecular-weight heparin calcium 5 000 u by subcutaneous injection every 12 hours for 7 - 10 days, simvastatin 20 mg every night for 8 weeks. The patients in control group were treated with 100 mg heparin plus 50 g · L^-1 glucose solution 500 mL byintravenous infusion for 7 - 10 d. Total cholesterol（ TC）, triglyeride（ TG）, low density lipoprotein（LDL-C） and high density lipoprotein（HDL） were detected before and after treatment in two groups, and the curative effect was evaluated. Results The total efficiency was significantly higher in observation group（92% ） than this in control group （76% ,P 〈0.05）. There was no significant difference in TC,TG,LDH-C and HDL-C between two groups before treatment （ P 〉 0.05 ）. There was no significant difference in TC, TG,LDH-C and HDL-C between pretreatment and posttreatment （P 〉 0.05 ）. HDL-C was increased, TC, LDH-C and TG were decreased after treatment in observation group, There was significant difference between pretreatment and posttreatment （P 〈 0.05 ）, There was significant difference in TC. TG. LDH-C and HDL-C between two groups after treatment （ P 〈 0. 05 ）. Conclusion Low molecular weight heparin calcium and simvastatin for treatment of UA was efficiently and safe.