绵萆薢化学成分研究

目的 研究绵草薢Dioscorea septemloba的化学成分.方法 用乙醇提取,石油醚、醋酸乙酯萃取,反复硅胶柱色谱技术分离纯化,根据理化性质,气质联用分析和光谱数据比较鉴定化学结构.结果 分离得到13个化合物,分别鉴定为4,8-甲基-1,7-壬二烯(Ⅰ)、5-异丙基-2,8-二甲基环癸酮(Ⅱ)、3,7-二甲基-6-辛烯-1-醇甲酯(Ⅲ)、十二酸甲酯(Ⅳ)、N,N'-二硝基-1,2-环己二胺(Ⅴ)、1-辛炔-4-醇(Ⅵ)、β-谷甾醇(Ⅶ)、棕榈酸(Ⅷ)、豆甾醇(Ⅸ)、6,7-二羟基-2-甲氧基-1,4-菲二酮(Ⅹ)、薯蓣皂苷元(Ⅺ)、鲁可斯皂苷元(Ⅻ)、豆甾醇-3-O-β-D-葡萄糖苷( ).结论 化合物Ⅰ～Ⅵ,Ⅸ、Ⅹ、Ⅻ、均为首次从该植物中分离得到.

Chemical constituents in Dioscorea septemloba

Objective To study the chemical constituents of Dioscorea septemloba. Methods The com- pounds were isolated by GC-MS and chromatography on silica gel column and identified on the basis of physico-chemical constants and spectral analysis. Results Thirteen compounds were isolated and their structures were identified as 4, 8-dimethyl-1, 7-nonadiene (Ⅰ), 5-isopropyl-2, 8-dimethylcyclodeca (Ⅱ), 3, 7-dimethyl-6-octen-1-ol-formate (Ⅲ), dodecanoic acid methyl easter (Ⅳ), N, N'-dinitro-1, 2 cyclo-hexanddiamine (Ⅴ), 1-octyn-4-ol (Ⅵ), β-sitosterol (Ⅶ), palmitic acid (Ⅷ), stigmasterol (Ⅸ), 6, 7-dihydroxy-2-methoxy-1, 4-phenanthrenedione (Ⅹ), diosgenin (Ⅺ), ruscogenin (Ⅻ), and stigmasterol-3-O-β-D-glucoside (ⅩⅢ ). Conclusion Compounds Ⅰ-Ⅵ, Ⅸ,Ⅹ,Ⅻ , and are obtained from this plant for the first time.