无负荷试验与脐血流测定评估妊娠期肝内胆汁淤积症患者围生儿预后

目的: 探讨脐动脉血流速度测定及无负荷试验评估妊娠期肝内胆汁淤积症(intrahepatic cholestasis of pregnancy,ICP)患者围生儿预后的应用价值。方法: 联合应用胎心无负荷试验及多普勒测定脐动脉血流速度,对71例ICP患者(ICP组)及60例正常孕妇(对照组)进行观察。结果: ICP组收缩期末和舒张期末峰值比(S/D)与无负荷试验异常发生率均高于对照组(P<0.05),ICP组的S/D和无负荷试验结果异常的围生儿预后不良发生率明显高于结果正常组(P<0.005)。结论: ICP患者应常规进行S/D测定及无负荷试验,以便及时处理改善围生儿预后。

Umbilical artery flow velocity examination and nonstretss test for predicting perinatal prognosis in patients with intrahepatic cholestasis in pregnancy

Objective:To study the value of umbilical artery flow velocity and nonstress test(NST) for patients with intrahepatic cholestasis in pregnancy(ICP).Methods:Fetal umbilical artery Doppler velocity and NST were used in 71 patients with ICP and 60 healthy women.Results:The incidence of S/D and abnormal NST was higher in the ICP group than that in the control group(P<(0.05)).The incidence of poor perinatal outcome in patients with abnormal S/D and NST was significantly higher than that of the control(P<0.005).Conclusions:Patients with ICP should receive examination of fetal umbilical artery blood flow and NST regularly in order to improve the perinatal prognosis.