不同剂量肝素经肺给药的血药浓度变化

目的：探讨不同剂量肝素经肺给药后血药浓度变化。方法：实验猪和慢性支气管炎（慢支）急性发作患者给予不同剂量肝素钠注射液，经气管切开和经纤支镜，定时检测给药后血药浓度。结果：实验猪经气管内注入１～８ｍｇ／ｋｇ肝素，血中可检出低浓度肝素１４ｄ，剂量与浓度无平行关系。慢支患者经纤支镜注入１００～２００ｍｇ肝素，血中可测出低浓度肝素１４ｄ，剂量与逍度也无平行关系。结论：肝素可经人肺及猪肺人血，不同剂量肝素（猪１～８ｍｇ／ｋｇ，人２～４ｍｇ／ｋｇ）经肺给药后血中可检出低浓度肝素１４ｄ，药物剂量与血药浓度无平行关系。

Change of the concentration of heparin in p;asma to different doses administered by the intrapulmonary route

AIM: To study the change of the concentration of heparin in plasma to different doses adminstered by the intrapulmonary route. METHODS: Experimental pigs or patients with chronic respiratory tract infection were given different doses of heparin through tracheotomy or fiberbronchuscope. Then their concentration of heparin in plasma was timely determined. RESULTS: After pigs were injected 1-8 mg/kg heparin via trachea, lower concentration of heparin in blood was found for 14 d. Likewise, after pations were administered 100-200 mg of heparin with fiberbronchuscope, lower concentration of heparin was found for 14 d. In both cases, there were no parallel relationship between the heparin doses and the plasma concentration. CONCLUSION: When heparin enters blood via human lungs or animal lungs, or when different doses of heparin 1-8 mg/kg in pigs, 2-4 mg/kg in patients are administered, lower concentration of heparin is found in the plasma for 14 d. No relationship is detected between the heparin doses and the plasma concentration.