Human papillomavirus is a favourable prognostic factor in tonsillar cancer and its oncogenic role is supported by the expression of E6 and E7 |
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| Authors: | David Lindquist, Mircea Romanitan, Lalle Hammarstedt, Anders N sman, Hanna Dahlstrand, Johan Lindholm, Liselotte Onel v, Torbj rn Ramqvist, Weimin Ye, Eva Munck-Wikland,Tina Dalianis |
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| Affiliation: | aDepartment of Oncology–Pathology, Karolinska Institutet, Cancer Center Karolinska, R8:01, Karolinska University Hospital, 171 76 Stockholm, Sweden;bDepartment of Oto-Rhino-Laryngology, Head and Neck Surgery, Karolinska Institutet, Karolinska University Hospital, 171 76 Stockholm, Sweden;cDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden |
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| Abstract: | From 1970 to 2002 in the Stockholm area, we revealed a parallel three-fold increase in the incidence of tonsillar cancer and the proportion of human papillomavirus (HPV) positive tonsillar cancer cases, indicating a possible role of HPV infection in this disease. We have now examined whether HPV and viral load in pre-treatment tonsillar cancer biopsies correlates to disease prognosis, and whether the presence of HPV-16 E6 and E7 mRNA could be ascertained. The presence of HPV-16, but not viral load, in tonsillar cancer was shown to be a favourable prognostic factor for clinical outcome. Moreover, E6 and/or E7 were expressed in almost all assessable HPV-16 positive cases, supporting an oncogenic role of HPV-16 in tonsillar cancer. |
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| Keywords: | Human papillomavirus Tonsillar carcinoma Head and neck squamous cell carcinoma Viral load E6 mRNA E7 mRNA |
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