血清学筛查在高龄孕妇产前诊断中应用价值分析

目的：探讨血清学筛查在高龄孕妇产前诊断中的应用价值。方法回顾性分析2012年1月1日-2012年10月31日行胎儿染色体核型分析的高龄孕妇314例，按预产期年龄分为35～39岁组和≥40岁组；按血清学筛查情况分为血清学筛查低危组、血清学筛查高危组和未做血清学筛查组，分析各组胎儿染色体异常率。结果胎儿染色体异常率4．14％（13/314）。≥40岁组胎儿染色体异常率13．21％（7/53），高于35～39岁组2．30％（6/261）（ P＝0．001）。血清学筛查高危组胎儿染色体异常率7．69％（7/91），高于血清学筛查低危组0（0/64）（ P＝0．022）。结论对高龄孕妇进行血清学筛查，有助于减少介入性产前诊断率。

Analyzing the Application of Prenatal Screening in Advanced Maternal Age

ObjectiveTo investigate the incidence of chromosome abnormalities in advanced maternal age(AMA), and to investigate the value of prenatal screening in AMA.MethodsRetrospective analysis of 314 cases of AMA which had invasive prenatal diagnosis.314 cases of AMA were divided into two groups according to expected date of childbirth age: 35~39 years old and older than 40 years old.And they were also divided into three groups according to serum screening: low risk serum screening group, high risk serum screening and without serum screeningand, to analyze the percentage of fetal chromosome abnormalities in these groups.ResultsThe percentage of fetal chromosomal abnormalities of 314 AMA was 4.14% (13/314).The percentage of fetal chromosomal abnormalities in AMA whose maternal age older than 40 years old was 13.21%(7/53), which was higher than that in AMA whose maternal age 35~39 years old 2.30% (6/261) (P=0.001).In high risk serum screening group, the percentage of fetal chromosome abnormalities was 7.69%(7/91), which was higher than that in low risk serum screening group 0 (0/64) (P=0.022).ConclusionsMaternal prenatal screening tests could be applied in AMA.