| 蘑芋葡甘聚糖对兔动脉粥样硬化的影响 |
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| 引用本文： | 高启军,万书平,杨广龙,魏辉,于晓玲.蘑芋葡甘聚糖对兔动脉粥样硬化的影响[J].中国康复,2010,25(3):170-172. |
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| 作者姓名： | 高启军 万书平 杨广龙 魏辉 于晓玲 |
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| 作者单位： | 1. 天门市第一人民医院心内科,湖北,天门,431700
2. 辽宁医学院附属第一医院心内科,辽宁,锦州,121001 |
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| 摘 要： | 目的:观察以膳食纤维蘑芋为主的蘑芋葡甘聚糖对兔动脉粥样硬化形成的影响及其机制。方法:将日本大耳兔24只,随机分成3组各8只,正常组喂普通饮食,模型组喂高脂饮食,蘑芋葡甘聚糖组(KGM组)喂高脂饮食+7.5%蘑芋葡甘聚糖。于实验开始前及实验第6、12周末时采血检测血脂中的总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)及低密度脂蛋白胆固醇(LDL-C),血清中超氧化物岐化酶(SOD)、氧化型低密度脂蛋白(ox-LDL)及C反应蛋白(CRP)。12周后处死动物,行主动脉HE染色,分析动脉粥样硬化的病理形态并比较组间的区别。结果:干预6周时,模型组及KGM组血脂各指标及ox-LDL、CRP与干预前及正常组比较均明显升高(P0.05,0.01),模型组高于KGM组(P0.01);SOD浓度,模型组KGM组正常组(P0.05,0.01)。干预12周后,与模型组比较,KGM组动脉粥样硬化程度显著减轻。结论:蘑芋葡甘聚糖能显著减轻高脂饮食所致兔动脉粥样硬化的程度。
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| 关 键 词： | 动脉粥样硬化 蘑芋葡甘聚糖 血脂 膳食纤维 |
Effect of Konjac Glucomannan on Atherosclerosis in Rabbits |
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| GAO Qi-jun,WAN Shu-ping,YANG Guang-long,et al..Effect of Konjac Glucomannan on Atherosclerosis in Rabbits[J].Chinese Journal of Rehabilitation,2010,25(3):170-172. |
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| Authors: | GAO Qi-jun WAN Shu-ping YANG Guang-long |
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| Institution: | GAO Qi-jun,WAN Shu-ping,YANG Guang-long,et al.Department of Internal Medicine,Tianmen First People's Hospital,Tianmen 431700,China |
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| Abstract: | Objective:To study the protective effect of konjac glucomannan(KGM)on atherosclerosis in rabbits.Methods:According to the serum level of total cholesterol,40 healthy male rabbits were randomly divided into 3 groups:group N(normal control)fed on normal food,group M(atherosclerosis model)fed on high-lipid diet,and group K(KGM)fed on high-lipid diet plus 7.5% KGM.In the morning of the D0,D42 and D91 the blood samples were collected and serum TC,TG,HDL-C,LDL-C,SOD,Ox-LDL and CRP were determined.At the end of th... |
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| Keywords: | atherosclerosis glucomannan lipid |
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